Inflammatory bowel disease - Revision history

Prab at 22:13, 26 April 2025

2025-04-26T22:13:35Z

← Older revision		Revision as of 22:13, 26 April 2025
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	* Weight loss		* Weight loss
	* Fatigue		* Fatigue
	[[File:Increased expression of CD74 (brown) in significant amounts in the proliferating crypt epithelial cells in the gut of inflammatory bowel disease (IBD) patient (Scale bar 50 Œºm).tif\|left\|thumb\|IBD]]
	==Cause==		==Cause==
	The exact cause of IBD is unknown, but IBD is the result of a defective immune system. A properly functioning immune system attacks foreign organisms, such as viruses and bacteria, to protect the body. In IBD, the immune system responds incorrectly to environmental triggers, which causes inflammation of the gastrointestinal tract. There also appears to be a genetic component‚Äîsomeone with a family history of IBD is more likely to develop this inappropriate immune response.		The exact cause of IBD is unknown, but IBD is the result of a defective immune system. A properly functioning immune system attacks foreign organisms, such as viruses and bacteria, to protect the body. In IBD, the immune system responds incorrectly to environmental triggers, which causes inflammation of the gastrointestinal tract. There also appears to be a genetic component‚Äîsomeone with a family history of IBD is more likely to develop this inappropriate immune response.

Prab: CSV import

2025-04-08T00:45:47Z

CSV import

← Older revision		Revision as of 00:45, 8 April 2025
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	* Inflammatory Bowel Disease (IBD) is a broad term that describes conditions characterized by chronic inflammation of the gastrointestinal tract. * The two most common inflammatory bowel diseases are [[ulcerative colitis]] and [[~~Crohn’s~~ disease]].		{{SI}}
	* Inflammation affects the entire digestive tract in ~~Crohn’s~~ disease and only the large intestine (also called the colon) in ulcerative colitis. * Both illnesses involved an abnormal response to the ~~body’s~~ immune system and are considered [[autoimmune disease]]s.		{{Infobox medical condition
	~~[[File:Cryptitis_high_mag.jpg\|thumb]]~~		\| name = Inflammatory bowel disease
			\| image = [[File:Cryptitis_high_mag.jpg\|250px]]
			\| caption = Micrograph showing cryptitis, a common feature of inflammatory bowel disease. H&E stain.
			\| field = [[Gastroenterology]]
			\| symptoms = [[Abdominal pain]], [[diarrhea]], [[rectal bleeding]], [[weight loss]], [[fatigue]]
			\| complications = [[Bowel obstruction]], [[colon cancer]], [[fistula]], [[abscess]]
			\| onset = Usually between ages 15 and 30
			\| duration = Long term
			\| types = [[Crohn's disease]], [[Ulcerative colitis]]
			\| causes = Unknown, possibly [[genetic]] and [[environmental factors]]
			\| risks = Family history, [[smoking]], [[nonsteroidal anti-inflammatory drugs]]
			\| diagnosis = [[Colonoscopy]], [[endoscopy]], [[biopsy]], [[stool test]], [[blood test]]
			\| differential = [[Irritable bowel syndrome]], [[celiac disease]], [[intestinal infection]]
			\| treatment = [[Anti-inflammatory drugs]], [[immunosuppressants]], [[biologics]], [[surgery]]
			\| medication = [[Aminosalicylates]], [[corticosteroids]], [[TNF inhibitors]]
			\| frequency = 1.3 million in the United States
			\| deaths = Rare, but complications can be fatal
			}}
			* Inflammatory Bowel Disease (IBD) is a broad term that describes conditions characterized by chronic inflammation of the gastrointestinal tract. * The two most common inflammatory bowel diseases are [[ulcerative colitis]] and [[Crohn‚Äôs disease]].
			* Inflammation affects the entire digestive tract in Crohn‚Äôs disease and only the large intestine (also called the colon) in ulcerative colitis. * Both illnesses involved an abnormal response to the body‚Äôs immune system and are considered [[autoimmune disease]]s.
	<youtube>		<youtube>
	title='''{{PAGENAME}}'''		title='''{{PAGENAME}}'''
	movie_url=http://www.youtube.com/v/chSyQPKsNk4		movie_url=http://www.youtube.com/v/chSyQPKsNk4
	&rel=1		&rel=1
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	height=600		height=600
	</youtube>		</youtube>

	==Crohn's disease and Ulcerative colitis==		==Crohn's disease and Ulcerative colitis==
	* Inflammatory bowel disease (IBD) is a term for two conditions (~~Crohn’s~~ disease and ulcerative colitis) that are characterized by chronic inflammation of the gastrointestinal (GI) tract.		* Inflammatory bowel disease (IBD) is a term for two conditions (Crohn‚Äôs disease and ulcerative colitis) that are characterized by chronic inflammation of the gastrointestinal (GI) tract.
	* Prolonged inflammation results in damage to the GI tract.		* Prolonged inflammation results in damage to the GI tract.
			Some of the differences between Crohn‚Äôs disease and ulcerative colitis:
	Some of the differences between ~~Crohn’s~~ disease and ulcerative colitis:		[[File:Crohn's Disease vs Colitis ulcerosa.svg\|alt=Crohn's Disease vs Colitis ulcerosa\|left\|thumb\|Crohn's Disease vs Colitis ulcerosa]]
	[[File:Crohn's Disease vs Colitis ulcerosa.svg\|alt=Crohn's Disease vs Colitis ulcerosa\|thumb\|Crohn's Disease vs Colitis ulcerosa]]
	===Crohn's disease===		===Crohn's disease===
	* Can affect any part of the GI tract (from the mouth to the anus)~~—Most~~ often it affects the portion of the small intestine before the large intestine/colon.		* Can affect any part of the GI tract (from the mouth to the anus)‚ÄîMost often it affects the portion of the small intestine before the large intestine/colon.
	* Damaged areas appear in patches that are next to areas of healthy tissue		* Damaged areas appear in patches that are next to areas of healthy tissue
	* Inflammation may reach through the multiple layers of the walls of the GI tract		* Inflammation may reach through the multiple layers of the walls of the GI tract

	===Ulcerative colitis===		===Ulcerative colitis===
	* Occurs in the large intestine (colon) and the rectum		* Occurs in the large intestine (colon) and the rectum
	* Damaged areas are continuous (not patchy) – usually starting at the rectum and spreading further into the colon		* Damaged areas are continuous (not patchy) – usually starting at the rectum and spreading further into the colon
	* Inflammation is present only in the innermost layer of the lining of the colon		* Inflammation is present only in the innermost layer of the lining of the colon

	==Signs and symptoms of IBD==		==Signs and symptoms of IBD==
	Some common symptoms are:		Some common symptoms are:
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	* Weight loss		* Weight loss
	* Fatigue		* Fatigue
	[[File:Increased expression of CD74 (brown) in significant amounts in the proliferating crypt epithelial cells in the gut of inflammatory bowel disease (IBD) patient (Scale bar 50 μm).tif\|thumb\|IBD]]		[[File:Increased expression of CD74 (brown) in significant amounts in the proliferating crypt epithelial cells in the gut of inflammatory bowel disease (IBD) patient (Scale bar 50 Œºm).tif\|left\|thumb\|IBD]]
	==Cause==		==Cause==
	The exact cause of IBD is unknown, but IBD is the result of a defective immune system. A properly functioning immune system attacks foreign organisms, such as viruses and bacteria, to protect the body. In IBD, the immune system responds incorrectly to environmental triggers, which causes inflammation of the gastrointestinal tract. There also appears to be a genetic ~~component—someone~~ with a family history of IBD is more likely to develop this inappropriate immune response.		The exact cause of IBD is unknown, but IBD is the result of a defective immune system. A properly functioning immune system attacks foreign organisms, such as viruses and bacteria, to protect the body. In IBD, the immune system responds incorrectly to environmental triggers, which causes inflammation of the gastrointestinal tract. There also appears to be a genetic component‚Äîsomeone with a family history of IBD is more likely to develop this inappropriate immune response.

	==Diagnosis==		==Diagnosis==
	IBD is diagnosed using a combination of endoscopy (for ~~Crohn’s~~ disease) or colonoscopy (for ulcerative colitis) and imaging studies, such as contrast radiography, magnetic resonance imaging (MRI), or computed tomography (CT). Physicians may also check stool samples to make sure symptoms are not being caused by an infection or run blood tests to help confirm the diagnosis.		IBD is diagnosed using a combination of endoscopy (for Crohn‚Äôs disease) or colonoscopy (for ulcerative colitis) and imaging studies, such as contrast radiography, magnetic resonance imaging (MRI), or computed tomography (CT). Physicians may also check stool samples to make sure symptoms are not being caused by an infection or run blood tests to help confirm the diagnosis.

	==Treatment==		==Treatment==
	Several types of medications may be used to treat IBD: aminosalicylates, corticosteroids (such as prednisone), immunomodulators, and the newest class approved for ~~IBD—the “biologics”~~. Several vaccinations for patients with IBD are recommended to prevent infections. Severe IBD may require surgery to remove damaged portions of the gastrointestinal tract, but advances in treatment with medications mean that surgery is less common than it was a few decades ago. Since ~~Crohn’s~~ disease and ulcerative colitis affect different parts of the GI tract, the surgical procedures are different for the two conditions.		Several types of medications may be used to treat IBD: aminosalicylates, corticosteroids (such as prednisone), immunomodulators, and the newest class approved for IBD‚Äîthe ‚Äúbiologics‚Äù. Several vaccinations for patients with IBD are recommended to prevent infections. Severe IBD may require surgery to remove damaged portions of the gastrointestinal tract, but advances in treatment with medications mean that surgery is less common than it was a few decades ago. Since Crohn‚Äôs disease and ulcerative colitis affect different parts of the GI tract, the surgical procedures are different for the two conditions.
	{{stub}}		{{stub}}
	{{Gastroenterology}}		{{Gastroenterology}}
	{{Crohn's disease and ulcerative colitis}}		{{Crohn's disease and ulcerative colitis}}
	{{Portal bar\|Biology\|Medicine}}		{{Portal bar\|Biology\|Medicine}}

	[[Category:Autoimmune diseases]]		[[Category:Autoimmune diseases]]
	[[Category:Gastrointestinal tract disorders]]		[[Category:Gastrointestinal tract disorders]]
	[[Category:Steroid-responsive inflammatory conditions]]		[[Category:Steroid-responsive inflammatory conditions]]

Prab at 14:25, 24 May 2023

2023-05-24T14:25:32Z

New page

* Inflammatory Bowel Disease (IBD) is a broad term that describes conditions characterized by chronic inflammation of the gastrointestinal tract. * The two most common inflammatory bowel diseases are [[ulcerative colitis]] and [[Crohn’s disease]].
* Inflammation affects the entire digestive tract in Crohn’s disease and only the large intestine (also called the colon) in ulcerative colitis. * Both illnesses involved an abnormal response to the body’s immune system and are considered [[autoimmune disease]]s.
[[File:Cryptitis_high_mag.jpg|thumb]]

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v/chSyQPKsNk4
&rel=1
embed_source_url=http://www.youtube.com/v/chSyQPKsNk4
&rel=1
wrap = yes
width=750
height=600
</youtube>

==Crohn's disease and Ulcerative colitis==
* Inflammatory bowel disease (IBD) is a term for two conditions (Crohn’s disease and ulcerative colitis) that are characterized by chronic inflammation of the gastrointestinal (GI) tract.
* Prolonged inflammation results in damage to the GI tract.

Some of the differences between Crohn’s disease and ulcerative colitis:
[[File:Crohn's Disease vs Colitis ulcerosa.svg|alt=Crohn's Disease vs Colitis ulcerosa|thumb|Crohn's Disease vs Colitis ulcerosa]]
===Crohn's disease===
* Can affect any part of the GI tract (from the mouth to the anus)—Most often it affects the portion of the small intestine before the large intestine/colon.
* Damaged areas appear in patches that are next to areas of healthy tissue
* Inflammation may reach through the multiple layers of the walls of the GI tract

===Ulcerative colitis===
* Occurs in the large intestine (colon) and the rectum
* Damaged areas are continuous (not patchy) – usually starting at the rectum and spreading further into the colon
* Inflammation is present only in the innermost layer of the lining of the colon

==Signs and symptoms of IBD==
Some common symptoms are:
* Persistent diarrhea
* Abdominal pain
* Rectal bleeding/bloody stools
* Weight loss
* Fatigue
[[File:Increased expression of CD74 (brown) in significant amounts in the proliferating crypt epithelial cells in the gut of inflammatory bowel disease (IBD) patient (Scale bar 50 μm).tif|thumb|IBD]]
==Cause==
The exact cause of IBD is unknown, but IBD is the result of a defective immune system. A properly functioning immune system attacks foreign organisms, such as viruses and bacteria, to protect the body. In IBD, the immune system responds incorrectly to environmental triggers, which causes inflammation of the gastrointestinal tract. There also appears to be a genetic component—someone with a family history of IBD is more likely to develop this inappropriate immune response.

==Diagnosis==
IBD is diagnosed using a combination of endoscopy (for Crohn’s disease) or colonoscopy (for ulcerative colitis) and imaging studies, such as contrast radiography, magnetic resonance imaging (MRI), or computed tomography (CT). Physicians may also check stool samples to make sure symptoms are not being caused by an infection or run blood tests to help confirm the diagnosis.

==Treatment==
Several types of medications may be used to treat IBD: aminosalicylates, corticosteroids (such as prednisone), immunomodulators, and the newest class approved for IBD—the “biologics”. Several vaccinations for patients with IBD are recommended to prevent infections. Severe IBD may require surgery to remove damaged portions of the gastrointestinal tract, but advances in treatment with medications mean that surgery is less common than it was a few decades ago. Since Crohn’s disease and ulcerative colitis affect different parts of the GI tract, the surgical procedures are different for the two conditions.
{{stub}}
{{Gastroenterology}}
{{Crohn's disease and ulcerative colitis}}
{{Portal bar|Biology|Medicine}}

[[Category:Autoimmune diseases]]
[[Category:Gastrointestinal tract disorders]]
[[Category:Steroid-responsive inflammatory conditions]]