https://wikimd.org/index.php?action=history&feed=atom&title=Indometacin_farnesilIndometacin farnesil - Revision history2026-04-27T23:06:34ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Indometacin_farnesil&diff=4967423&oldid=prevPrab at 11:56, 9 September 20232023-09-09T11:56:19Z<p></p>
<p><b>New page</b></p><div>[[File:Infree.png|thumb|Indometacin farnesil]]<br />
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'''Indometacin farnesil''' is a pharmaceutical compound recognized by its [[International Nonproprietary Name|INN]]. Acting as a [[prodrug]], it serves as a precursor to the more widely recognized [[non-steroidal anti-inflammatory drug]] (NSAID) known as [[indometacin]].<br />
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== Overview ==<br />
The primary rationale behind the creation of indometacin farnesil was to circumvent some of the adverse effects commonly associated with indometacin. This was achieved by esterifying the carboxyl group present on indometacin using [[farnesol]], a process that can reduce the potential for certain side-effects.<br />
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== Approval and Availability ==<br />
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=== Japan ===<br />
Indometacin farnesil received its initial approval in [[Japan]] in 1991. It is commercially available in the country under the trade name '''Infree'''.<br />
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=== Indonesia ===<br />
In addition to Japan, indometacin farnesil is also available in [[Indonesia]]. Here, the medication can be found under the trade name '''Dialon'''.<br />
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== Pharmacological Mechanism ==<br />
As a [[prodrug]], indometacin farnesil is biologically inactive in its administered form. Once inside the body, however, it is metabolized to release the active NSAID, indometacin. This transformation allows for the therapeutic effects of indometacin to be realized, while the esterification with farnesol aims to mitigate the drug's side-effects.<br />
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== See Also ==<br />
* [[Non-steroidal anti-inflammatory drug]]<br />
* [[Prodrug]]<br />
* [[Indometacin]]<br />
* [[Farnesol]]<br />
== External links ==<br />
*[http://di.eisai.co.jp/di/EPI/INF_C-SC_EPI.pdf Infree prescribing information] from [[Eisai Co.]]<br />
{{NSAIDs}}<br />
[[Category:Non-steroidal anti-inflammatory drugs]]<br />
[[Category:Indoles]]<br />
{{drugs}} [[Category:Prodrugs]]<br />
[[Category:Sesquiterpenes]]<br />
[[Category:Organochlorides]]<br />
[[Category:Benzamides]]<br />
{{musculoskeletal-drug-stub}}<br />
[[Category:Drugs]]<br />
[[Category:Prodrugs]]<br />
[[Category:Anti-inflammatory agents]]<br />
__NOTOC__</div>Prab