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2025-02-18T04:59:44Z

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← Older revision		Revision as of 04:59, 18 February 2025
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			<gallery>
			File:Indinavir_structure.svg\|Chemical structure of Indinavir
			File:Indinavir_ball-and-stick.png\|Ball-and-stick model of Indinavir
			File:2avo_Indinavir.png\|Indinavir bound to HIV protease (PDB: 2AVO)
			File:HIV_protease-indinavir_complex.jpg\|HIV protease complexed with Indinavir
			</gallery>

Prab: Created page with " {{intro}} Indinavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodefi..."

2019-05-01T14:03:45Z

Created page with " {{intro}} Indinavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodefi..."

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{{intro}}
Indinavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus ([[HIV]]) infection and the acquired immunodeficiency syndrome ([[AIDS]]).

{{livtox}}
Indinavir can cause transient and usually asymptomatic elevations in serum [[aminotransferase]] levels and mild elevations in indirect bilirubin concentration. Indinavir is a rare cause of clinically apparent, acute [[liver injury]]. In HBV or HCV coinfected patients, antiretroviral therapy with indinavir may result in an exacerbation of the underlying chronic hepatitis B or C.

{{moa}}
Indinavir (in din' a vir) is an antiretroviral protease inhibitor that acts by binding to the catalytic site of the [[HIV]] protease, thereby preventing the cleavage of viral polyprotein precursors into mature, functional proteins that are necessary for viral replication.

{{fda}}
{{PAGENAME}} was approved for use in the United States in 1996 and continues to be commonly used in combination with other antiretroviral agents for the treatment of [[HIV]] infection. Indinavir is available under the brand name Crixivan in capsules of 100, 200 and 400 mg. Indinavir is typically used in combination with a low dose of ritonavir, which improves its pharmacokinetics.

{{dose}}
The recommended dosage of indinavir is 800 mg orally every 8 hours with or without ritonavir (usually 100 to 200 mg twice daily).

{{se}}
Side effects can include [[gastrointestinal upset]], [[nausea]], [[diarrhea]], back pain, fatigue and, with long term use, hyperlipidemia and lipodystrophy.
{{antiviral agents}}
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Indinavir - Revision history

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Prab: Created page with " {{intro}} Indinavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodefi..."