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			<gallery>
			File:Indazole_2D_numbered.svg\|Indazole structure with numbered atoms
			File:Fischer_indazole.png\|Fischer indazole synthesis
			File:Marsanidine.svg\|Marsanidine structure
			</gallery>

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'''Indazole''' is an organic compound and a heterocycle, which is a cyclic compound that has atoms of at least two different elements as members of its rings. It is a pyrazole derivative, with a nitrogen atom replacing one carbon atom in the ring. The compound is isomeric with [[imidazole]] and [[pyrazole]].

== Structure and synthesis ==

Indazole has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrazole ring. The compound is planar and aromatic, with the aromaticity being delocalized over the entire structure.

Indazole can be synthesized by the reaction of phenylhydrazine with [[formaldehyde]] in the presence of a base, followed by acidification. This reaction is known as the [[Fischer indazole synthesis]], named after the German chemist [[Emil Fischer]] who first reported it.

== Properties and reactions ==

Indazole is a colorless solid that is slightly soluble in water. It is more soluble in organic solvents such as [[ethanol]] and [[dichloromethane]].

Indazole can undergo a variety of chemical reactions. For example, it can react with electrophiles at the 3-position of the pyrazole ring. It can also undergo [[nucleophilic substitution]] reactions at the 1-position.

== Uses ==

Indazole and its derivatives have a wide range of uses in organic chemistry and medicinal chemistry. They are used as building blocks in the synthesis of more complex molecules, and as ligands in coordination chemistry.

In medicinal chemistry, indazole derivatives have been investigated for their potential therapeutic properties. For example, they have been studied as potential anti-inflammatory, analgesic, antiviral, and anticancer agents.

== See also ==

* [[Benzimidazole]]
* [[Benzotriazole]]
* [[Indole]]

== References ==

<references />

[[Category:Organic compounds]]
[[Category:Heterocyclic compounds]]
[[Category:Pyrazoles]]
[[Category:Indazoles]]

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Indazole - Revision history

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