https://wikimd.com/index.php?action=history&feed=atom&title=ITGAE ITGAE - Revision history 2026-04-21T16:39:50Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=ITGAE&diff=6509865&oldid=prev Prab: CSV import 2025-03-17T14:51:44Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:51, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l21">Line 21:</td> <td colspan="2" class="diff-lineno">Line 21:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=ITGAE&diff=6251372&oldid=prev Prab: CSV import 2025-02-10T20:20:19Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:20, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l20">Line 20:</td> <td colspan="2" class="diff-lineno">Line 20:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=ITGAE&diff=5381190&oldid=prev Prab: CSV import 2024-03-10T12:29:55Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;ITGAE&#039;&#039;&#039; (Integrin Subunit Alpha E) is a protein coding gene located on the human chromosome 17. The protein encoded by this gene is a member of the integrin family of cell surface receptors, which mediate cell-cell and cell-extracellular matrix interactions. <br /> <br /> == Function ==<br /> The ITGAE gene encodes a protein that is a member of the [[integrin]] family. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha E chain. Unlike other integrin alpha chains, alpha E undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. This protein associates with the beta 7 subunit to form the integrin [[heterodimer]] alpha4beta7, which plays a role in [[immune response]] by adhering to its ligand [[mucosal addressin cell adhesion molecule-1]] (MAdCAM-1) expressed on the high endothelial venules of Peyer&#039;s patches. The alpha E subunit is also a receptor for the [[Epstein-Barr virus]] (EBV), a human herpes virus associated with [[cancer]] and [[autoimmune disease]].<br /> <br /> == Clinical Significance ==<br /> Mutations in the ITGAE gene have been associated with [[inflammatory bowel disease]] (IBD). The ITGAE protein is expressed in the [[gut]] and is involved in the adhesion of [[lymphocytes]] to the gut epithelium. This interaction is thought to play a role in the pathogenesis of IBD. <br /> <br /> == See Also ==<br /> * [[Integrin]]<br /> * [[Inflammatory bowel disease]]<br /> * [[Epstein-Barr virus]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> [[Category:Genes]]<br /> [[Category:Human proteins]]<br /> [[Category:Cell biology]]<br /> [[Category:Immunology]]<br /> {{medicine-stub}}</div> Prab