IRAK1 - Revision history

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	[[Category:Immune system]]		[[Category:Immune system]]
	[[Category:Kinases]]		[[Category:Kinases]]
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			File:Toll-like receptor pathways revised.jpg\|Toll-like receptor pathways revised
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	~~== Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) ==~~

	~~[[File:IRAK1 Toll-like_receptor_pathways_revised.jpg\|thumb\|right\|Diagram of IRAK1 in Toll-like receptor pathways]]~~

	'''Interleukin-1 Receptor-Associated Kinase 1''' ('''IRAK1''') is a critical kinase involved in the signaling pathways of the [[immune system]]. It plays a pivotal role in the [[Toll-like receptor]] (TLR) and [[interleukin-1 receptor]] (IL-1R) signaling pathways, which are essential for the innate immune response.		'''Interleukin-1 Receptor-Associated Kinase 1''' ('''IRAK1''') is a critical kinase involved in the signaling pathways of the [[immune system]]. It plays a pivotal role in the [[Toll-like receptor]] (TLR) and [[interleukin-1 receptor]] (IL-1R) signaling pathways, which are essential for the innate immune response.

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	'''~~IRAK1~~''' or '''~~Interleukin-1 receptor-associated kinase 1~~''' is a [[~~protein~~]] ~~that~~ in ~~humans is encoded by~~ the ~~IRAK1~~ [[~~gene~~]]~~. It is a member of the~~ [[~~Interleukin~~-1 receptor~~-associated kinases~~]] ~~family~~, which is a ~~group~~ of ~~enzymes that play a key role in~~ the [[~~Innate immune system\|innate immune response~~]] to [[~~bacteria~~]].		== Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) ==

			[[File:IRAK1 Toll-like_receptor_pathways_revised.jpg\|thumb\|right\|Diagram of IRAK1 in Toll-like receptor pathways]]

			'''Interleukin-1 Receptor-Associated Kinase 1''' ('''IRAK1''') is a critical kinase involved in the signaling pathways of the [[immune system]]. It plays a pivotal role in the [[Toll-like receptor]] (TLR) and [[interleukin-1 receptor]] (IL-1R) signaling pathways, which are essential for the innate immune response.

			== Structure ==
			IRAK1 is a serine/threonine kinase that is part of the IRAK family, which also includes [[IRAK2]], [[IRAK3]] (also known as IRAK-M), and [[IRAK4]]. The structure of IRAK1 includes an N-terminal death domain, a central kinase domain, and a C-terminal domain that is involved in protein-protein interactions.

	== Function ==		== Function ==
	IRAK1 is ~~a [[serine/threonine~~-protein ~~kinase]] that plays a critical role in initiating~~ [[~~immune response~~]] ~~against foreign pathogens~~. ~~It acts as a mediator~~ of ~~[[Toll-like~~ receptor]] and [[~~Interleukin-1 receptor~~]] ~~signaling pathways, which are necessary for immune response activation~~.		IRAK1 is activated upon the engagement of TLRs or IL-1R by their respective ligands. Upon activation, IRAK1 is recruited to the receptor complex through interactions with the adaptor protein [[MyD88]]. This recruitment leads to the phosphorylation and activation of IRAK1, which subsequently dissociates from the receptor complex and interacts with downstream signaling molecules such as [[TRAF6]].

	~~== Clinical significance ==~~		The activation of IRAK1 leads to the activation of the [[NF-_B]] and [[MAPK]] signaling pathways, resulting in the transcription of pro-inflammatory cytokines and other immune response genes.
	~~Mutations in~~ the ~~IRAK1 gene have been associated with [[autoimmune diseases]] such as~~ [[~~Systemic lupus erythematosus~~]] and [[~~rheumatoid arthritis~~]]~~. In addition~~, ~~IRAK1 has been implicated~~ in the ~~development~~ of ~~[[cancer]], particularly [[breast cancer]]~~ and ~~[[leukemia]]~~.

	== ~~See also~~ ==		== Role in Disease ==
	* [[~~Interleukin-1 receptor-associated kinases~~]]		Dysregulation of IRAK1 activity has been implicated in various inflammatory and autoimmune diseases. Overactivation of IRAK1 can lead to excessive production of inflammatory cytokines, contributing to conditions such as [[rheumatoid arthritis]], [[systemic lupus erythematosus]], and [[inflammatory bowel disease]]. Conversely, impaired IRAK1 function can result in increased susceptibility to infections.
	* [[~~Toll-like receptor~~]]
	* [[~~Innate immune system~~]]

	== ~~References~~ ==		== Therapeutic Target ==
	~~<references />~~		Given its central role in immune signaling, IRAK1 is considered a potential therapeutic target for the treatment of inflammatory and autoimmune diseases. Inhibitors of IRAK1 are being investigated for their ability to modulate immune responses and reduce inflammation.

	== ~~External links~~ ==		== Related Pages ==
	* [~~https://www.ncbi.nlm.nih.gov/gene/3654 IRAK1~~] ~~at the~~ [[~~National Center for Biotechnology Information~~]]		* [[Toll-like receptor]]
			* [[Interleukin-1 receptor]]
			* [[MyD88]]
			* [[NF-_B]]
			* [[MAPK]]

	[[Category:~~Proteins]]~~		[[Category:Signal transduction]]
	~~[[Category:Genes~~]]
	[[Category:Immune system]]		[[Category:Immune system]]
	[[Category:~~Medical genetics~~]]		[[Category:Kinases]]
	~~[[Category:Oncology]]~~
	~~[[Category:Rheumatology]]~~

	~~{{stub}}~~

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'''IRAK1''' or '''Interleukin-1 receptor-associated kinase 1''' is a [[protein]] that in humans is encoded by the IRAK1 [[gene]]. It is a member of the [[Interleukin-1 receptor-associated kinases]] family, which is a group of enzymes that play a key role in the [[Innate immune system|innate immune response]] to [[bacteria]].

== Function ==
IRAK1 is a [[serine/threonine-protein kinase]] that plays a critical role in initiating [[immune response]] against foreign pathogens. It acts as a mediator of [[Toll-like receptor]] and [[Interleukin-1 receptor]] signaling pathways, which are necessary for immune response activation.

== Clinical significance ==
Mutations in the IRAK1 gene have been associated with [[autoimmune diseases]] such as [[Systemic lupus erythematosus]] and [[rheumatoid arthritis]]. In addition, IRAK1 has been implicated in the development of [[cancer]], particularly [[breast cancer]] and [[leukemia]].

== See also ==
* [[Interleukin-1 receptor-associated kinases]]
* [[Toll-like receptor]]
* [[Innate immune system]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/3654 IRAK1] at the [[National Center for Biotechnology Information]]

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Immune system]]
[[Category:Medical genetics]]
[[Category:Oncology]]
[[Category:Rheumatology]]

{{stub}}