https://wikimd.org/index.php?action=history&feed=atom&title=IMP-1088 2026-04-25T14:25:03Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=IMP-1088&diff=5369685&oldid=prev 2024-03-06T06:59:06Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:IMP-1088.svg|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;IMP-1088&#039;&#039;&#039; is a potent and selective [[enzyme inhibitor]] that targets [[N-myristoyltransferase]] (NMT), an enzyme involved in the post-translational modification of proteins. IMP-1088 was developed by researchers at the [[Imperial College London]] and the [[Francis Crick Institute]].<br /> <br /> == Mechanism of Action ==<br /> <br /> IMP-1088 works by inhibiting the function of NMT. NMT is responsible for the addition of a 14-carbon fatty acid, myristate, to the N-terminal glycine of a subset of proteins, a process known as [[N-myristoylation]]. This modification is crucial for the function of these proteins, many of which are involved in cellular signaling and the life cycle of viruses.<br /> <br /> IMP-1088 is a dual inhibitor of both NMT1 and NMT2, the two isoforms of NMT found in humans. By inhibiting these enzymes, IMP-1088 prevents the myristoylation of proteins, disrupting their function and leading to the death of cells dependent on these proteins.<br /> <br /> == Applications ==<br /> <br /> The primary application of IMP-1088 is in the field of [[virology]]. Many viruses, including the [[human rhinovirus]], the cause of the common cold, rely on host NMT for replication. By inhibiting NMT, IMP-1088 can prevent the replication of these viruses, potentially providing a new approach to antiviral therapy.<br /> <br /> In addition to its antiviral properties, IMP-1088 has potential applications in cancer therapy. Many cancers are driven by proteins that rely on N-myristoylation for their function. By inhibiting NMT, IMP-1088 could potentially disrupt the function of these proteins, providing a new approach to cancer therapy.<br /> <br /> == Research ==<br /> <br /> Research into IMP-1088 is ongoing. Early studies have shown that it is a potent inhibitor of NMT and has potential as an antiviral and anticancer agent. However, further research is needed to fully understand its mechanism of action and potential applications.<br /> <br /> == See Also ==<br /> * [[Enzyme inhibitor]]<br /> * [[N-myristoyltransferase]]<br /> * [[N-myristoylation]]<br /> * [[Virology]]<br /> * [[Cancer therapy]]<br /> <br /> [[Category:Enzyme inhibitors]]<br /> [[Category:Antiviral agents]]<br /> [[Category:Anticancer agents]]<br /> [[Category:Pharmacology]]<br /> <br /> {{Pharmacology-stub}}</div>

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