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	'''IL17RB''' is a ~~human gene~~ that ~~encodes for~~ the ~~protein Interleukin 17 receptor B~~. This ~~protein~~ is ~~a member~~ of the [[interleukin receptor]] family and plays a crucial role in mediating the ~~immune~~ response ~~of the body~~.
			{{Infobox protein
			\| name = Interleukin-17 receptor B
			\| symbol = IL17RB
			\| HGNCid = 5983
			\| OMIM = 605458
			\| EntrezGene = 55540
			\| RefSeq = NM_018725
			\| UniProt = Q9NRM6
			}}

			'''Interleukin-17 receptor B''' ('''IL17RB''') is a protein that in humans is encoded by the '''IL17RB''' gene. This receptor is part of the interleukin-17 receptor family and plays a crucial role in the immune system by mediating the inflammatory response.

	== Function ==		== Function ==
			IL17RB is primarily expressed in [[immune cells]] and is known to bind to [[interleukin-17E]] (also known as [[IL-25]]). This interaction is important for the activation of [[NF-kB]] and the production of [[pro-inflammatory cytokines]]. The receptor is involved in the regulation of [[Th2 immune responses]], which are critical in the defense against [[helminth infections]] and in the pathogenesis of [[allergic diseases]].
	~~The~~ IL17RB ~~gene~~ is ~~responsible for encoding the IL17RB protein, which~~ is ~~a part of the~~ [[interleukin 17]] (~~IL17) family. This family consists of six ligands (IL17A-F) and five receptors (IL17RA-E). The IL17RB protein specifically binds with the ligands IL17B and IL17E,~~ also known as ~~IL25~~. This ~~binding initiates a signaling cascade that leads to~~ the activation of the ~~nuclear factor kappa-light-chain-enhancer~~ of ~~activated B cells (~~[[NF-kB]]~~) pathway~~. ~~This pathway plays a significant role~~ in the regulation of immune responses, ~~including inflammation and~~ the defense against ~~pathogens~~.

	== Clinical Significance ==		== Clinical Significance ==
			Alterations in the expression of IL17RB have been associated with various [[inflammatory diseases]] and [[autoimmune disorders]]. Studies have shown that IL17RB may play a role in the development of [[asthma]], [[allergic rhinitis]], and [[inflammatory bowel disease]]. Additionally, IL17RB has been implicated in certain [[cancers]], where it may influence tumor growth and metastasis.
	Alterations in the IL17RB ~~gene~~ have been associated with ~~several~~ diseases. ~~Overexpression of~~ IL17RB ~~has been observed~~ in ~~various types~~ of ~~cancers~~, ~~including breast cancer~~ and ~~pancreatic cancer~~. It has ~~also~~ been ~~linked to allergic diseases such as asthma~~ and ~~atopic dermatitis~~.

	== Research ==		== Research ==
			Ongoing research is focused on understanding the precise mechanisms by which IL17RB contributes to immune regulation and its potential as a therapeutic target. Inhibitors of IL17RB signaling are being explored as possible treatments for [[autoimmune diseases]] and [[chronic inflammatory conditions]].
	~~Research~~ is ~~ongoing to understand~~ the ~~exact role of~~ IL17RB ~~in disease progression~~ and ~~to explore~~ potential therapeutic ~~targets~~. ~~Some studies suggest that blocking~~ IL17RB ~~may be a potential strategy~~ for ~~treating certain types of cancer~~ and ~~allergic diseases.~~

	[[~~File:IL17RB Gene Location.png\|thumb\|right\|300px\|Location of the IL17RB gene on chromosome 3~~]]

	== See Also ==		== See Also ==
			* [[Interleukin-17 family]]
	* [[Interleukin 17]]		* [[Cytokine receptor]]
	* [[~~Interleukin~~ receptor]]		* [[Immune system]]
	* [[~~NF-kB~~]]

	== References ==		== References ==
			{{Reflist}}

	~~<references~~ />		== External Links ==
			* [https://www.ncbi.nlm.nih.gov/gene/55540 IL17RB Gene - NCBI]
			* [https://www.uniprot.org/uniprot/Q9NRM6 IL17RB Protein - UniProt]

	~~[[Category:Genes]]~~
	[[Category:Human proteins]]		[[Category:Human proteins]]
	[[Category:~~Immunology~~]]		[[Category:Immune system]]
	[[Category:~~Oncology~~]]		[[Category:Cytokine receptors]]
	~~[[Category:Allergy]]~~

	~~{{Genes on human chromosome 3}}~~
	~~{{Immunology-stub}}~~
	~~{{medicine-stub}}~~

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'''IL17RB''' is a human gene that encodes for the protein Interleukin 17 receptor B. This protein is a member of the [[interleukin receptor]] family and plays a crucial role in mediating the immune response of the body.

== Function ==

The IL17RB gene is responsible for encoding the IL17RB protein, which is a part of the [[interleukin 17]] (IL17) family. This family consists of six ligands (IL17A-F) and five receptors (IL17RA-E). The IL17RB protein specifically binds with the ligands IL17B and IL17E, also known as IL25. This binding initiates a signaling cascade that leads to the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells ([[NF-kB]]) pathway. This pathway plays a significant role in the regulation of immune responses, including inflammation and the defense against pathogens.

== Clinical Significance ==

Alterations in the IL17RB gene have been associated with several diseases. Overexpression of IL17RB has been observed in various types of cancers, including breast cancer and pancreatic cancer. It has also been linked to allergic diseases such as asthma and atopic dermatitis.

== Research ==

Research is ongoing to understand the exact role of IL17RB in disease progression and to explore potential therapeutic targets. Some studies suggest that blocking IL17RB may be a potential strategy for treating certain types of cancer and allergic diseases.

[[File:IL17RB Gene Location.png|thumb|right|300px|Location of the IL17RB gene on chromosome 3]]

== See Also ==

* [[Interleukin 17]]
* [[Interleukin receptor]]
* [[NF-kB]]

== References ==

<references />

[[Category:Genes]]
[[Category:Human proteins]]
[[Category:Immunology]]
[[Category:Oncology]]
[[Category:Allergy]]

{{Genes on human chromosome 3}}
{{Immunology-stub}}
{{medicine-stub}}

IL17RB - Revision history

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