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	<id>https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=IL-4</id>
	<title>IL-4 - Revision history</title>
	<link rel="self" type="application/atom+xml" href="https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=IL-4"/>
	<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=IL-4&amp;action=history"/>
	<updated>2026-04-21T01:07:43Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
	<generator>MediaWiki 1.44.2</generator>
	<entry>
		<id>https://wikimd.com/index.php?title=IL-4&amp;diff=6524345&amp;oldid=prev</id>
		<title>Prab at 12:47, 18 March 2025</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=IL-4&amp;diff=6524345&amp;oldid=prev"/>
		<updated>2025-03-18T12:47:16Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 12:47, 18 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l42&quot;&gt;Line 42:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 42:&lt;/td&gt;&lt;/tr&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{No image}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{No image}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;__NOINDEX__&lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-added&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=IL-4&amp;diff=6509408&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=IL-4&amp;diff=6509408&amp;oldid=prev"/>
		<updated>2025-03-17T14:25:29Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 14:25, 17 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l42&quot;&gt;Line 42:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 42:&lt;/td&gt;&lt;/tr&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=IL-4&amp;diff=6258924&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=IL-4&amp;diff=6258924&amp;oldid=prev"/>
		<updated>2025-02-10T21:05:15Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 21:05, 10 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l41&quot;&gt;Line 41:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 41:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{stub}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{stub}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{dictionary-stub1}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{dictionary-stub1}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;{{No image}}&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=IL-4&amp;diff=5257268&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=IL-4&amp;diff=5257268&amp;oldid=prev"/>
		<updated>2024-02-24T03:55:21Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;IL-4&amp;#039;&amp;#039;&amp;#039; or &amp;#039;&amp;#039;&amp;#039;Interleukin 4&amp;#039;&amp;#039;&amp;#039; is a type of [[interleukin]] that is a [[cytokine]] produced by [[T cells]] in response to [[antigen]] stimulation. It has many roles in the [[immune system]], including the stimulation of activated [[B-cell]] and [[T-cell]] proliferation, and the differentiation of [[B cells]] into [[plasma cell]]s. It is a key regulator in [[humoral]] and [[adaptive immunity]].&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
&lt;br /&gt;
IL-4 induces [[B-cell]] class switching to [[IgE]], and up-regulates [[MHC class II]] production. IL-4 decreases the production of [[Th1]] cells, [[macrophages]], [[IFN-gamma]], and [[dendritic cell]] IL-12. Overproduction of IL-4 is associated with [[allergies]].&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
&lt;br /&gt;
IL-4 has been associated with several diseases including [[asthma]], [[rheumatoid arthritis]], and [[cancer]]. It is also involved in the pathogenesis of [[allergies]] and [[autoimmune diseases]].&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
&lt;br /&gt;
* [[Interleukin]]&lt;br /&gt;
* [[Cytokine]]&lt;br /&gt;
* [[T cells]]&lt;br /&gt;
* [[B cells]]&lt;br /&gt;
* [[Plasma cell]]&lt;br /&gt;
* [[Humoral immunity]]&lt;br /&gt;
* [[Adaptive immunity]]&lt;br /&gt;
* [[MHC class II]]&lt;br /&gt;
* [[Th1 cells]]&lt;br /&gt;
* [[Macrophages]]&lt;br /&gt;
* [[IFN-gamma]]&lt;br /&gt;
* [[Dendritic cell]]&lt;br /&gt;
* [[IL-12]]&lt;br /&gt;
* [[Allergies]]&lt;br /&gt;
* [[Asthma]]&lt;br /&gt;
* [[Rheumatoid arthritis]]&lt;br /&gt;
* [[Cancer]]&lt;br /&gt;
* [[Autoimmune diseases]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Interleukins]]&lt;br /&gt;
[[Category:Cytokines]]&lt;br /&gt;
[[Category:Immune system]]&lt;br /&gt;
[[Category:Allergies]]&lt;br /&gt;
[[Category:Asthma]]&lt;br /&gt;
[[Category:Rheumatoid arthritis]]&lt;br /&gt;
[[Category:Cancer]]&lt;br /&gt;
[[Category:Autoimmune diseases]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;br /&gt;
{{dictionary-stub1}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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