https://wikimd.com/index.php?action=history&feed=atom&title=IFT140IFT140 - Revision history2026-04-20T12:40:55ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=IFT140&diff=5787574&oldid=prevPrab: CSV import2024-05-16T03:49:56Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Ideogram_human_chromosome_16.svg|thumb|Ideogram human chromosome 16]] '''IFT140'''<br />
'''IFT140''' is a gene that encodes a protein involved in intraflagellar transport, a process essential for the assembly and maintenance of cilia. Cilia are hair-like structures found on the surface of many cells and play crucial roles in various cellular functions, including cell signaling and movement.<br />
== Function ==<br />
The protein encoded by IFT140 is a component of the intraflagellar transport complex B (IFT-B), which is responsible for transporting cargo proteins along the ciliary axoneme. This transport process is crucial for the proper formation and function of cilia.<br />
== Clinical Significance ==<br />
Mutations in the IFT140 gene have been associated with various ciliopathies, a group of genetic disorders characterized by defects in cilia structure and function. These disorders can affect multiple organ systems and lead to a range of symptoms, including vision and hearing impairment, kidney abnormalities, and skeletal defects.<br />
== Research ==<br />
Research on IFT140 and other genes involved in cilia formation and function is ongoing, with the goal of better understanding the molecular mechanisms underlying ciliopathies and developing potential therapeutic strategies.<br />
== See also ==<br />
* [[Ciliopathy]]<br />
* [[Intraflagellar transport]]<br />
* [[Cilium]]<br />
[[Category:Genes]]<br />
[[Category:Cell biology]]<br />
[[Category:Genetics]]<br />
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