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	The process of administering high-dose chemotherapy typically involves several steps:		The process of administering high-dose chemotherapy typically involves several steps:

	1. Preparation: Patients undergo a series of tests to ensure they are fit for the treatment.		1. '''Preparation''': Patients undergo a series of tests to ensure they are fit for the treatment.
	2. Stem cell collection: Before chemotherapy, stem cells are collected from the patient or a donor.		2. '''Stem cell collection''': Before chemotherapy, stem cells are collected from the patient or a donor.
	3. Chemotherapy administration: High doses of chemotherapy drugs are administered, usually over a period of several days.		3. '''Chemotherapy administration''': High doses of chemotherapy drugs are administered, usually over a period of several days.
	4. Stem cell transplant: After chemotherapy, the collected stem cells are infused back into the patient to aid in the recovery of the bone marrow.		4. '''Stem cell transplant''': After chemotherapy, the collected stem cells are infused back into the patient to aid in the recovery of the bone marrow.

	==Side effects==		==Side effects==

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{{Short description|Overview of high-dose chemotherapy in cancer treatment}}

==High-dose chemotherapy==
[[File:Chemotherapy_iv_(1).jpg|Chemotherapy being administered intravenously|thumb|right]]
High-dose chemotherapy (HDC) is a form of [[cancer treatment]] that involves administering higher than standard doses of [[chemotherapy]] drugs. The primary goal of HDC is to eradicate [[cancer cells]] more effectively by using increased concentrations of chemotherapeutic agents. This approach is often used in conjunction with [[hematopoietic stem cell transplantation]] to restore the bone marrow function that is compromised by the high doses of chemotherapy.

==Mechanism of action==
Chemotherapy works by targeting rapidly dividing cells, a characteristic of cancer cells. High-dose chemotherapy amplifies this effect by increasing the concentration of drugs, thereby enhancing their ability to kill cancer cells. However, this also increases the risk of damage to normal, healthy cells, particularly those in the [[bone marrow]], [[gastrointestinal tract]], and [[hair follicles]].

==Applications==
High-dose chemotherapy is primarily used in the treatment of certain types of [[cancer]], including:

* [[Lymphoma]]
* [[Multiple myeloma]]
* [[Leukemia]]
* [[Breast cancer]]
* [[Germ cell tumors]]

The use of HDC is often followed by a [[stem cell transplant]], which helps to replenish the bone marrow cells destroyed by the chemotherapy.

==Procedure==
The process of administering high-dose chemotherapy typically involves several steps:

1. **Preparation**: Patients undergo a series of tests to ensure they are fit for the treatment.
2. **Stem cell collection**: Before chemotherapy, stem cells are collected from the patient or a donor.
3. **Chemotherapy administration**: High doses of chemotherapy drugs are administered, usually over a period of several days.
4. **Stem cell transplant**: After chemotherapy, the collected stem cells are infused back into the patient to aid in the recovery of the bone marrow.

==Side effects==
[[File:Stomach_pain.jpg|Stomach pain, a common side effect of chemotherapy|thumb|left]]
The side effects of high-dose chemotherapy can be more severe than those of standard chemotherapy due to the higher drug concentrations. Common side effects include:

* [[Nausea]] and [[vomiting]]
* [[Stomach pain]]
* [[Fatigue]]
* [[Infections]] due to low white blood cell counts
* [[Hair loss]]

[[File:Male-pattern_hair_loss.jpg|Hair loss, a common side effect of chemotherapy|thumb|right]]

==Recovery and prognosis==
Recovery from high-dose chemotherapy can be challenging and requires careful monitoring and supportive care. The prognosis depends on various factors, including the type and stage of cancer, the patient's overall health, and how well the cancer responds to treatment.

==Related pages==
* [[Chemotherapy]]
* [[Stem cell transplant]]
* [[Cancer treatment]]
* [[Bone marrow]]

[[File:Bone_Marrow_Transplant.png|Bone marrow transplant, often used in conjunction with high-dose chemotherapy|thumb|left]]

[[Category:Cancer treatments]]
[[Category:Chemotherapy]]

High-dose chemotherapy - Revision history

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