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Hepatocyte nuclear factor 4 alpha - Revision history
2026-04-25T06:40:23Z
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2025-02-10T19:01:09Z
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<p><b>New page</b></p><div>'''Hepatocyte nuclear factor 4 alpha''' ('''HNF4A'''), also known as '''nuclear receptor subfamily 2 group A member 1''' ('''NR2A1'''), is a [[nuclear receptor]] that in humans is encoded by the ''HNF4A'' [[gene]]. It is a member of the nuclear receptor superfamily of [[transcription factors]].<br />
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== Function ==<br />
HNF4A is a nuclear transcription factor that binds [[DNA]] as a [[homodimer]]. It controls the expression of several genes, including [[hepatocyte]] nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines.<br />
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== Clinical significance ==<br />
Mutations in this gene have been associated with [[monogenic diabetes mellitus]] of the young type 1 (MODY1) and [[hepatocellular adenoma]].<br />
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== Interactions ==<br />
HNF4A has been shown to [[protein-protein interaction|interact]] with:<br />
* [[CREB-binding protein]]<br />
* [[Hepatocyte nuclear factor 1-alpha]]<br />
* [[Peroxisome proliferator-activated receptor gamma coactivator 1-alpha]]<br />
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== See also ==<br />
* [[Hepatocyte nuclear factor]]<br />
* [[HNF4G]]<br />
* [[HNF4B]]<br />
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== References ==<br />
<references /><br />
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== External links ==<br />
* [http://www.genecards.org/cgi-bin/carddisp.pl?gene=HNF4A GeneCards: HNF4A]<br />
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[[Category:Transcription factors]]<br />
[[Category:Nuclear receptors]]<br />
[[Category:Human proteins]]<br />
[[Category:Genes on human chromosome 20]]<br />
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