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← Older revision		Revision as of 21:19, 23 February 2025
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	[[Category:Genetic Disorders]]		[[Category:Genetic Disorders]]
	[[Category:Dermatology]]		[[Category:Dermatology]]
			<gallery>
			File:SAND_Maurice_Masques_et_bouffons_01.jpg\|SAND Maurice Masques et bouffons 01
			File:A_scene_from_the_commedia_dell'_arte_played_in_France_before_a_noble_audience_-_Ferrone_2014_fig34.jpg\|A scene from the commedia dell'arte played in France before a noble audience - Ferrone 2014 fig34
			File:Compositions_de_rhétorique_de_Mr._Don_Arlequin,_1601,_p01_(title_page_Arlechin)_-_Gallica_2010_(adjusted).jpg\|Compositions de rhétorique de Mr. Don Arlequin, 1601, p01 (title page Arlechin) - Gallica 2010 (adjusted)
			File:Tivoli_Gardens_-_Harlequin.jpg\|Tivoli Gardens - Harlequin
			File:Arlequin,_par_Paul_Cézanne,_NGA.jpg\|Arlequin, par Paul Cézanne, NGA
			File:ARTSTOR_103_41822003063748.jpg\|ARTSTOR 103 41822003063748
			File:ClownHarlequinPayne.jpg\|Clown Harlequin Payne
			</gallery>

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2024-02-23T16:35:41Z

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'''Harlequin''' is a term used in various fields of study, including [[medicine]], [[genetics]], and [[dermatology]]. In the medical field, it is often associated with a rare and severe skin condition known as [[Harlequin Ichthyosis]].

== Overview ==

[[Harlequin Ichthyosis]] is a severe genetic disorder that mainly affects the skin. Infants with this condition are born with very hard, thick skin covering most of their bodies. The skin forms large, diamond-shaped plates that are separated by deep cracks (fissures). These skin abnormalities affect the shape of the eyelids, nose, mouth, and ears, and limit movement of the arms and legs. Restricted movement of the chest can lead to breathing difficulties and respiratory failure.

== Causes ==

[[Harlequin Ichthyosis]] is caused by mutations in the [[ABCA12]] gene. The ABCA12 gene provides instructions for making a protein that is essential for normal skin development. This protein plays a major role in transporting fats (lipids) in the outermost layer of skin (the epidermis). Mutations in the ABCA12 gene disrupt the normal development of the epidermis, leading to the hard, thick scales seen in people with harlequin ichthyosis.

== Treatment ==

Treatment for [[Harlequin Ichthyosis]] is supportive and aims to manage the symptoms and complications. This may include intensive care and isolation to prevent infection, use of retinoids to promote shedding of the skin, and various therapies to manage associated complications.

== See Also ==

* [[Ichthyosis]]
* [[Genetic Disorders]]
* [[Dermatology]]

== References ==

<references />

{{stub}}

[[Category:Medical Conditions]]
[[Category:Genetic Disorders]]
[[Category:Dermatology]]

Harlequin - Revision history

Prab: CSV import

Prab: CSV import