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<p><b>New page</b></p><div>'''Haptocorrin''' (also known as '''HC''', '''R-factor''', or '''transcobalamin I''') is a [[glycoprotein]] that binds to [[vitamin B12]] and carries it through the [[stomach]] and into the [[intestine]]. It is one of three proteins, along with [[intrinsic factor]] and [[transcobalamin]], that bind to vitamin B12, but it is unique in that it is resistant to acid and proteolysis in the stomach.<br />
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== Function ==<br />
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Haptocorrin is produced in the [[salivary glands]] and is secreted into the saliva. It binds to vitamin B12 as soon as it enters the mouth, protecting it from the acidic environment of the stomach. Once in the intestine, the vitamin B12 is released from the haptocorrin and is then bound by intrinsic factor, which facilitates its absorption by the [[enterocytes]].<br />
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== Clinical significance ==<br />
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Haptocorrin levels can be measured in the blood and can be used as a marker for certain diseases. Low levels of haptocorrin can indicate a deficiency in vitamin B12, while high levels can indicate a number of conditions, including [[liver disease]], [[kidney disease]], and certain types of [[cancer]].<br />
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== See also ==<br />
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* [[Vitamin B12]]<br />
* [[Intrinsic factor]]<br />
* [[Transcobalamin]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Proteins]]<br />
[[Category:Glycoproteins]]<br />
[[Category:Vitamin B12]]<br />
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