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'''HOT-2''' (also known as '''2,5-dimethoxy-4-ethylthioamphetamine''') is a [[psychedelic phenethylamine]] of the [[2C family]]. It was first synthesized by [[Alexander Shulgin]] and documented in his book, ''[[PiHKAL]]'' (Phenethylamines I Have Known And Loved).

== History ==

HOT-2 was first synthesized and studied by Alexander Shulgin. The detailed synthesis and personal bioassay information was published in his book ''PiHKAL''. The compound is part of a series of psychedelic phenethylamines, collectively referred to as the HOT series, which were developed by Shulgin for their psychoactive properties.

== Chemistry ==

HOT-2 is a derivative of [[2C-H]], which is a primary amine of the 2C family. The chemical structure consists of a phenethylamine core, with an additional ethylthio group attached to the 4th position of the phenyl ring, and two methoxy groups attached at the 2nd and 5th positions.

== Pharmacology ==

Like other psychedelic phenethylamines, HOT-2 is thought to act primarily as a [[5-HT2A receptor]] agonist. This receptor is involved in the release of the neurotransmitter [[serotonin]], which plays a role in regulating mood, appetite, sleep, and other functions. The exact mechanism of action, however, is not fully understood.

== Effects ==

The effects of HOT-2 are similar to other psychedelic phenethylamines, and can include visual hallucinations, enhanced perception, euphoria, and altered thought patterns. The duration of effects typically lasts between 6 to 8 hours, but can vary depending on the dose and individual metabolism.

== Legal Status ==

The legal status of HOT-2 varies by country. In the United States, it is not specifically listed as a controlled substance, but it could potentially be considered an analog of a controlled substance under the [[Federal Analogue Act]].

== See Also ==

* [[2C-E]]
* [[2C-I]]
* [[2C-T-2]]
* [[2C-T-7]]
* [[2C-B]]
* [[2C-C]]

[[Category:Psychedelic phenethylamines]]
[[Category:Alexander Shulgin]]
[[Category:Psychoactive drugs]]
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HOT-2 - Revision history

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