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2024-02-22T17:47:47Z

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'''HMGA1''' is a protein that in humans is encoded by the HMGA1 gene. This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.

== Function ==

The '''HMGA1''' protein is associated with the [[chromosome]] and has a high affinity for the [[AT-hook]] motif, a DNA-binding motif found in a variety of proteins. This protein is involved in several cellular processes, including [[transcription]] regulation, [[retrovirus]] integration, and [[metastasis]] progression in cancer cells.

== Clinical significance ==

Alterations in the '''HMGA1''' gene are associated with new [[oncogene]]s and can lead to [[neoplastic transformation]]. Overexpression of this gene has been found in a variety of human cancers, including [[breast cancer]], [[prostate cancer]], and [[leukemia]].

== See also ==

* [[HMGA]]
* [[AT-hook]]
* [[Oncogene]]
* [[Neoplastic transformation]]
* [[Breast cancer]]
* [[Prostate cancer]]
* [[Leukemia]]

== References ==

<references />

== External links ==

* [https://www.ncbi.nlm.nih.gov/gene/3159 HMGA1] at the National Center for Biotechnology Information

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Oncogenes]]
[[Category:Cancer]]
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HMGA1 - Revision history

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