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'''HLA-DR9''' is a [[human leukocyte antigen]] serotype within the [[HLA-DR]] serotype group. The serotype is determined by the antibody recognition of [[HLA-DRB1*09]] and *1001. This broad antigen group is produced by the [[Major Histocompatibility Complex]] (MHC), a gene complex in humans that plays a crucial role in immune response.

== Function ==

HLA-DR9, like other HLA-DR antigens, is involved in the immune system's recognition of foreign substances. It presents [[peptide (biochemistry)|peptides]] derived from extracellular proteins to [[T cells]], which are a type of white blood cell. This presentation triggers an immune response, leading to the destruction of cells containing the foreign substance.

== Association with Diseases ==

HLA-DR9 has been associated with several autoimmune and inflammatory diseases. These include [[rheumatoid arthritis]], [[systemic lupus erythematosus]], and [[type 1 diabetes]]. The exact mechanism of this association is not fully understood, but it is believed to involve the antigen's role in immune response.

== Distribution ==

HLA-DR9 is found in varying frequencies in different populations. It is most common in East Asian populations, particularly in Japan and China. It is less common in European and African populations.

== See Also ==

* [[HLA-DR]]
* [[Human leukocyte antigen]]
* [[Major Histocompatibility Complex]]
* [[Autoimmune disease]]

== References ==

<references />

[[Category:HLA serotypes]]
[[Category:Immunology]]
[[Category:Genetics]]
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HLA-DR9 - Revision history

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Prab: CSV import