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HLA-DR3 - Revision history
2026-04-27T08:22:57Z
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<p><b>New page</b></p><div>'''HLA-DR3''' is a [[human leukocyte antigen]] serotype within the [[HLA-DR]] serotype group. The serotype is determined by the antibody recognition of [[antigen]]s. HLA-DR3 is a split antigen of the broad antigen [[HLA-DR17]], which is now obsolete. HLA-DR3 is associated with several [[autoimmune diseases]], including [[type 1 diabetes]], [[coeliac disease]], and [[systemic lupus erythematosus]].<br />
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== Structure and Function ==<br />
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HLA-DR3 is a cell surface [[glycoprotein]] that plays a crucial role in the [[immune system]]. It is part of the [[major histocompatibility complex]] (MHC) class II, which presents antigens to the [[T cell]]s. The HLA-DR3 antigen is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane.<br />
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== Disease Associations ==<br />
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HLA-DR3 is associated with a variety of autoimmune diseases. These include:<br />
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* '''[[Type 1 diabetes]]''': HLA-DR3 and [[HLA-DR4]] are the most common serotypes associated with this disease. The presence of these serotypes increases the risk of developing type 1 diabetes.<br />
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* '''[[Coeliac disease]]''': HLA-DR3 is found in up to 95% of patients with coeliac disease. The presence of HLA-DR3 is a strong predictor of the development of coeliac disease.<br />
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* '''[[Systemic lupus erythematosus]]''': HLA-DR3 is associated with an increased risk of developing systemic lupus erythematosus, particularly in individuals of European descent.<br />
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== See Also ==<br />
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* [[HLA-DR]]<br />
* [[Human leukocyte antigen]]<br />
* [[Major histocompatibility complex]]<br />
* [[Autoimmune disease]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Human leukocyte antigens]]<br />
[[Category:Immunology]]<br />
[[Category:Autoimmune diseases]]<br />
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