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<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;HLA-DR15&#039;&#039;&#039; is a [[human leukocyte antigen]] serotype within the [[HLA-DR]] serogroup. The serotype is determined by the antibody recognition of [[HLA-DRB1*15]] and *16 gene products. This broad antigen group is produced by two similar genes, [[HLA-DRB1]] and [[HLA-DRB5]], which are inherited together. HLA-DR15 and HLA-DR51 are commonly inherited together and are linked with several autoimmune conditions and diseases.<br /> <br /> == Structure and Function ==<br /> <br /> HLA-DR15 is a part of the [[Major Histocompatibility Complex]] (MHC) class II molecules, which are expressed in antigen-presenting cells (APCs). The primary function of these molecules is to present processed antigenic peptides to T cells. HLA-DR15, like other MHC class II molecules, is a heterodimer consisting of an alpha (DRA) and beta chain (DRB), the latter being encoded by HLA-DRB1 or HLA-DRB5 genes.<br /> <br /> == Association with Diseases ==<br /> <br /> HLA-DR15 has been associated with a number of autoimmune diseases. These include [[multiple sclerosis]], [[rheumatoid arthritis]], and [[systemic lupus erythematosus]]. It is also associated with a higher risk of [[narcolepsy]], [[Hodgkin&#039;s lymphoma]], and [[pemphigus vulgaris]].<br /> <br /> == Clinical Significance ==<br /> <br /> The presence of HLA-DR15 can be determined through [[HLA typing]], which can be useful in predicting susceptibility to certain diseases. However, it is not used as a diagnostic tool due to the complex nature of these diseases.<br /> <br /> == See Also ==<br /> <br /> * [[HLA-DR]]<br /> * [[Human leukocyte antigen]]<br /> * [[Major Histocompatibility Complex]]<br /> * [[Autoimmune disease]]<br /> <br /> == References ==<br /> <br /> &lt;references /&gt;<br /> <br /> [[Category:Immunology]]<br /> [[Category:Human leukocyte antigen]]<br /> [[Category:Autoimmune diseases]]<br /> [[Category:Genetics]]<br /> <br /> {{medicine-stub}}</div>

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