https://wikimd.org/index.php?action=history&feed=atom&title=HLA-DQ8 2026-04-27T04:36:01Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=HLA-DQ8&diff=5803578&oldid=prev 2024-05-19T22:32:42Z

<p>CSV import</p> <p><b>New page</b></p><div>[[file:HLA-DQ8_insulin.png|thumb|left]] [[file:DQ8-Insulin_peptide.PNG|thumb|left]] &#039;&#039;&#039;HLA-DQ8&#039;&#039;&#039; is a [[human leukocyte antigen]] (HLA) serotype within the HLA-DQ (DQ) class II antigen family. It is encoded by the [[HLA-DQA1]] and [[HLA-DQB1]] genes. HLA-DQ8 is one of the most studied HLA types due to its strong association with several [[autoimmune diseases]].<br /> <br /> ==Genetics==<br /> HLA-DQ8 is encoded by the alleles [[HLA-DQA1|DQA1*03]] and [[HLA-DQB1|DQB1*03:02]]. These alleles are located on the short arm of [[chromosome 6]] at position 6p21.3. The DQ8 molecule is a heterodimer consisting of an alpha chain (DQA1*03) and a beta chain (DQB1*03:02).<br /> <br /> ==Function==<br /> The primary function of HLA-DQ8, like other HLA class II molecules, is to present [[antigen]]s to [[CD4+ T cells]]. This process is crucial for the activation of the [[immune system]] and the initiation of an immune response. HLA-DQ8 is involved in the presentation of peptides derived from extracellular proteins.<br /> <br /> ==Association with Diseases==<br /> HLA-DQ8 is strongly associated with several autoimmune diseases, including:<br /> * [[Type 1 diabetes]]: HLA-DQ8 is one of the major genetic risk factors for type 1 diabetes. It is present in a significant proportion of individuals with the disease.<br /> * [[Celiac disease]]: HLA-DQ8, along with [[HLA-DQ2]], is associated with celiac disease. Individuals with these HLA types are at a higher risk of developing the disease.<br /> * [[Rheumatoid arthritis]]: HLA-DQ8 has been implicated in the susceptibility to rheumatoid arthritis.<br /> <br /> ==Clinical Relevance==<br /> The presence of HLA-DQ8 can be determined through genetic testing. This information can be useful in the diagnosis and management of autoimmune diseases. For example, in individuals with a family history of type 1 diabetes or celiac disease, the presence of HLA-DQ8 can indicate an increased risk of developing these conditions.<br /> <br /> ==See Also==<br /> * [[HLA-DQ]]<br /> * [[HLA-DQ2]]<br /> * [[HLA-DQA1]]<br /> * [[HLA-DQB1]]<br /> * [[Autoimmune disease]]<br /> * [[Type 1 diabetes]]<br /> * [[Celiac disease]]<br /> * [[Rheumatoid arthritis]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==External Links==<br /> {{Commons category|HLA-DQ8}}<br /> <br /> [[Category:Immunology]]<br /> [[Category:Genetics]]<br /> [[Category:Autoimmune diseases]]<br /> [[Category:Human leukocyte antigens]]<br /> <br /> {{medicine-stub}}</div>

Prab