https://wikimd.com/index.php?action=history&feed=atom&title=HLA-DOHLA-DO - Revision history2026-04-22T04:55:50ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=HLA-DO&diff=5297455&oldid=prevPrab: CSV import2024-02-25T20:55:25Z<p>CSV import</p>
<p><b>New page</b></p><div>'''HLA-DO''' is a protein that in humans is encoded by the HLA-DOA and HLA-DOB genes. HLA-DO is an intracellular heterodimer that plays a critical role in the presentation of antigens to the immune system. It is part of the [[Major Histocompatibility Complex]] (MHC) class II molecules, which are expressed in antigen-presenting cells (APCs).<br />
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== Structure ==<br />
HLA-DO is composed of two non-covalently associated subunits, alpha (DOA) and beta (DOB). The alpha chain is encoded by the HLA-DOA gene, while the beta chain is encoded by the HLA-DOB gene. Both genes are located within the MHC class II region on chromosome 6.<br />
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== Function ==<br />
HLA-DO functions as a negative regulator of the immune response. It inhibits the peptide loading of [[MHC class II]] molecules by blocking the binding of the invariant chain (Ii) and the HLA-DM molecule. This results in a reduced ability of the immune system to respond to foreign antigens.<br />
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== Clinical significance ==<br />
Alterations in the expression of HLA-DO have been associated with various autoimmune diseases, including [[rheumatoid arthritis]] and [[multiple sclerosis]]. Further research is needed to fully understand the role of HLA-DO in these conditions.<br />
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== See also ==<br />
* [[Major Histocompatibility Complex]]<br />
* [[MHC class II]]<br />
* [[Antigen-presenting cell]]<br />
* [[Autoimmune disease]]<br />
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== References ==<br />
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[[Category:Human proteins]]<br />
[[Category:Immune system]]<br />
[[Category:Genes on human chromosome 6]]<br />
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