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'''HDAC6''' (Histone Deacetylase 6) is a [[enzyme|enzyme]] that in humans is encoded by the ''HDAC6'' [[gene|gene]]. It is a member of the [[histone deacetylase]] family, which is involved in a multitude of cellular processes, such as [[cell cycle|cell cycle progression]], [[gene expression]], and [[protein folding]].

== Function ==
HDAC6 is unique among the class II HDAC enzymes in that it contains two complete, functional deacetylase domains. This enzyme has been shown to deacetylate [[tubulin]], HSP90, and cortactin, proteins involved in [[cell motility]] and [[vesicle transport]]. It plays a central role in [[microtubule]]-dependent cell motility via the deacetylation of tubulin.

== Clinical significance ==
HDAC6 has been implicated in a variety of human diseases, including [[cancer]], [[neurodegenerative diseases]], and [[inflammatory diseases]]. In cancer, HDAC6 is frequently overexpressed and has been associated with tumor progression and [[chemotherapy]] resistance. In neurodegenerative diseases, HDAC6 is thought to be involved in the formation of [[aggregated proteins]] and the induction of [[cell death]].

== Inhibitors ==
Several [[HDAC inhibitors]] have been developed to target HDAC6, including [[tubastatin A]], [[ricolinostat]], and [[ACY-1215]]. These inhibitors have shown promise in preclinical and clinical trials for the treatment of various diseases, particularly cancer.

== See also ==
* [[Histone deacetylase]]
* [[HDAC inhibitors]]
* [[Tubulin]]

== References ==
<references />

[[Category:Enzymes]]
[[Category:Genes]]
[[Category:Cell biology]]
[[Category:Medicine]]

{{medicine-stub}}

HDAC6 - Revision history

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