https://wikimd.com/index.php?action=history&feed=atom&title=HDAC4 2026-04-24T15:28:10Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=HDAC4&diff=5377886&oldid=prev 2024-03-09T21:09:10Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;HDAC4&#039;&#039;&#039; or &#039;&#039;&#039;Histone Deacetylase 4&#039;&#039;&#039; is a [[gene]] that encodes a member of the class II histone deacetylase family. Proteins encoded by this gene are involved in the regulation of [[transcription]], the process by which genetic information from [[DNA]] is copied into [[RNA]]. <br /> <br /> == Function ==<br /> HDAC4 is a [[histone deacetylase]] that can bind to the [[transcription factor]] MEF2 and repress its activity. The encoded protein can also form a complex with other transcription factors and with [[myocyte enhancer factor 2]] (MEF2) proteins, thereby inhibiting MEF2-dependent genes, which play a role in muscle differentiation. <br /> <br /> == Structure ==<br /> The HDAC4 protein is composed of 1084 [[amino acids]] and has a molecular weight of approximately 122 kDa. It contains a histone deacetylase catalytic domain and a [[nuclear localization signal]] (NLS), which allows it to shuttle between the [[cytoplasm]] and the [[nucleus]].<br /> <br /> == Clinical Significance ==<br /> Mutations in the HDAC4 gene have been associated with [[brachydactyly mental retardation syndrome]], a rare genetic disorder characterized by intellectual disability and short fingers and toes. In addition, HDAC4 has been implicated in the pathogenesis of [[cancer]], [[neurodegenerative diseases]], and [[cardiovascular diseases]].<br /> <br /> == Research ==<br /> Research on HDAC4 has focused on its role in [[cell differentiation]], [[apoptosis]], and [[cell cycle]] regulation. It has been found to be a key regulator of [[osteoblast]] differentiation and bone development. In addition, it has been implicated in the regulation of [[neuronal]] survival and death.<br /> <br /> == See Also ==<br /> * [[Histone Deacetylase]]<br /> * [[Transcription (genetics)]]<br /> * [[Brachydactyly mental retardation syndrome]]<br /> * [[Cell differentiation]]<br /> * [[Apoptosis]]<br /> * [[Cell cycle]]<br /> <br /> [[Category:Genes]]<br /> [[Category:Proteins]]<br /> [[Category:Enzymes]]<br /> [[Category:Histone deacetylases]]<br /> <br /> {{medicine-stub}}</div>

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