https://wikimd.org/index.php?action=history&feed=atom&title=HBE1HBE1 - Revision history2026-04-26T10:14:20ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=HBE1&diff=5299274&oldid=prevPrab: CSV import2024-02-25T21:52:24Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Hemoglobin subunit epsilon''' ('''HBE1''') is a protein that in humans is encoded by the ''HBE1'' gene. The protein product is a component of hemoglobin, the molecule responsible for transporting oxygen in the blood. The ''HBE1'' gene is part of the beta globin gene cluster, which also includes the genes ''HBB'', ''HBD'', ''HBBP1'', and ''HBG1/2''.<br />
<br />
== Function ==<br />
The ''HBE1'' gene provides instructions for making a protein called epsilon globin. Epsilon globin combines with alpha globin (produced from the ''HBA1'' and ''HBA2'' genes) to form hemoglobin in the developing fetus. Hemoglobin is the molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs.<br />
<br />
== Clinical significance ==<br />
Mutations in the ''HBE1'' gene can cause hemoglobin H disease ([[Hemoglobin H disease]]), a form of alpha thalassemia. This condition is characterized by a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, and more serious complications.<br />
<br />
== See also ==<br />
* [[Hemoglobin]]<br />
* [[Alpha thalassemia]]<br />
* [[Beta globin]]<br />
<br />
== References ==<br />
<references /><br />
<br />
== External links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/3047 NCBI Gene]<br />
* [https://ghr.nlm.nih.gov/gene/HBE1 Genetics Home Reference]<br />
<br />
[[Category:Human proteins]]<br />
[[Category:Genes on human chromosome 11]]<br />
{{stub}}<br />
<br />
This article incorporates text from the United States National Library of Medicine, which is in the public domain.</div>Prab