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	<title>H1 antagonist - Revision history</title>
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	<updated>2026-04-27T14:27:13Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.org/index.php?title=H1_antagonist&amp;diff=6330554&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
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		<updated>2025-02-20T00:40:43Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 00:40, 20 February 2025&lt;/td&gt;
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		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=H1_antagonist&amp;diff=5205380&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=H1_antagonist&amp;diff=5205380&amp;oldid=prev"/>
		<updated>2024-02-22T03:40:17Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;H1 antagonist&amp;#039;&amp;#039;&amp;#039; is a type of [[drug]] that blocks the action of [[histamine]] at the H1 receptor, effectively reducing the symptoms of [[allergy]] and [[hypersensitivity]] reactions. H1 antagonists are commonly used in the treatment of [[allergic rhinitis]], [[urticaria]], and other allergic reactions.&lt;br /&gt;
&lt;br /&gt;
== Mechanism of Action ==&lt;br /&gt;
&lt;br /&gt;
H1 antagonists work by selectively blocking the [[H1 receptor]], a protein found on the surface of certain cells in the body. This receptor is responsible for mediating the effects of histamine, a chemical that is released during an allergic reaction. By blocking the H1 receptor, these drugs prevent histamine from binding to its receptor, thereby reducing the symptoms of an allergic reaction.&lt;br /&gt;
&lt;br /&gt;
== Types of H1 Antagonists ==&lt;br /&gt;
&lt;br /&gt;
There are two main types of H1 antagonists: first-generation and second-generation.&lt;br /&gt;
&lt;br /&gt;
=== First-Generation H1 Antagonists ===&lt;br /&gt;
&lt;br /&gt;
First-generation H1 antagonists, such as [[diphenhydramine]] and [[chlorpheniramine]], are older drugs that are effective at reducing the symptoms of an allergic reaction. However, they can cause side effects such as drowsiness and dry mouth.&lt;br /&gt;
&lt;br /&gt;
=== Second-Generation H1 Antagonists ===&lt;br /&gt;
&lt;br /&gt;
Second-generation H1 antagonists, such as [[cetirizine]], [[loratadine]], and [[fexofenadine]], are newer drugs that are less likely to cause drowsiness and other side effects. They are also longer acting, meaning they can be taken less frequently.&lt;br /&gt;
&lt;br /&gt;
== Uses ==&lt;br /&gt;
&lt;br /&gt;
H1 antagonists are used to treat a variety of conditions, including:&lt;br /&gt;
&lt;br /&gt;
* [[Allergic rhinitis]]&lt;br /&gt;
* [[Urticaria]]&lt;br /&gt;
* [[Allergic conjunctivitis]]&lt;br /&gt;
* [[Anaphylaxis]]&lt;br /&gt;
* [[Pruritus]]&lt;br /&gt;
* [[Motion sickness]]&lt;br /&gt;
* [[Insomnia]]&lt;br /&gt;
&lt;br /&gt;
== Side Effects ==&lt;br /&gt;
&lt;br /&gt;
Like all drugs, H1 antagonists can cause side effects. These may include:&lt;br /&gt;
&lt;br /&gt;
* Drowsiness&lt;br /&gt;
* Dry mouth&lt;br /&gt;
* Blurred vision&lt;br /&gt;
* Constipation&lt;br /&gt;
* Urinary retention&lt;br /&gt;
&lt;br /&gt;
== See Also ==&lt;br /&gt;
&lt;br /&gt;
* [[H2 antagonist]]&lt;br /&gt;
* [[Histamine]]&lt;br /&gt;
* [[Allergy]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Pharmacology]]&lt;br /&gt;
[[Category:Drugs]]&lt;br /&gt;
[[Category:Allergy]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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