https://wikimd.com/index.php?action=history&feed=atom&title=Granulation_tissueGranulation tissue - Revision history2026-04-09T05:20:22ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Granulation_tissue&diff=6317600&oldid=prevPrab: CSV import2025-02-18T04:34:54Z<p>CSV import</p>
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</table>Prabhttps://wikimd.com/index.php?title=Granulation_tissue&diff=5245265&oldid=prevPrab: CSV import2024-02-23T15:03:51Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Granulation tissue''' is a kind of tissue generated in a healing wound to both support the healing process and lay the groundwork for the growth of new tissue. It is typically characterized by its pink or red appearance and its granular surface. <br />
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==Formation==<br />
The formation of granulation tissue is usually the first step in the healing process. This occurs after the initial (inflammatory) phase of wound healing, which is characterized by swelling, redness, heat, and pain. The formation of granulation tissue involves the proliferation of [[fibroblasts]] and [[endothelial cells]], which are stimulated by various growth factors such as [[platelet-derived growth factor]] (PDGF), [[vascular endothelial growth factor]] (VEGF), and [[fibroblast growth factor]] (FGF).<br />
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==Characteristics==<br />
Granulation tissue is composed of a matrix of [[collagen]] and [[proteoglycans]] that is highly vascularized and often edematous (swollen due to fluid buildup). It also contains a large number of [[macrophages]], which are cells that help to clean the wound and fight infection. The tissue is typically pink or red in color due to the presence of newly formed [[capillaries]].<br />
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==Role in Wound Healing==<br />
The primary role of granulation tissue is to fill the wound space and provide a supportive structure for the growth of new tissue. It also helps to protect the wound from infection and further injury. Once the wound is filled with granulation tissue, the process of [[epithelialization]] (the growth of new skin) can begin.<br />
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==Clinical Significance==<br />
In some cases, the formation of granulation tissue can be excessive, leading to a condition known as [[hypergranulation]] or "proud flesh". This can delay wound healing and may require treatment. On the other hand, insufficient formation of granulation tissue can also impede wound healing.<br />
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==See Also==<br />
* [[Wound healing]]<br />
* [[Fibroblast]]<br />
* [[Endothelial cell]]<br />
* [[Macrophage]]<br />
* [[Collagen]]<br />
* [[Proteoglycan]]<br />
* [[Capillary]]<br />
* [[Epithelialization]]<br />
* [[Hypergranulation]]<br />
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[[Category:Medicine]]<br />
[[Category:Pathology]]<br />
[[Category:Histology]]<br />
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