Gestodene - Revision history

Prab: CSV import

2025-02-21T14:15:09Z

CSV import

← Older revision		Revision as of 14:15, 21 February 2025
Line 1:		Line 1:
	== Gestodene ==		== Gestodene ==

	~~'''Gestodene''' is a synthetic~~ [[~~progestogen]] used in [[hormonal contraception]]~~. ~~It is a third-generation progestin, which is often combined with [[estrogen~~]]~~s in [[combined oral contraceptive pill]]s. Gestodene is known for its high progestational activity and low androgenic activity, making it a popular choice in contraceptive formulations.~~		[[File:Gestodene.svg\|thumb\|right\|Chemical structure of Gestodene]]

	~~=== Chemical Properties ===~~		'''Gestodene''' is a synthetic [[progestogen]] used in [[hormonal contraception]]. It is a third-generation progestin, which is often combined with an [[estrogen]] such as [[ethinylestradiol]] in [[combined oral contraceptive pill\|combined oral contraceptive pills]].
	Gestodene is a ~~derivative of~~ [[~~19-nortestosterone~~]]~~, which is a common structural basis for many synthetic progestins~~. It ~~has the chemical formula C21H26O2 and~~ a ~~molecular weight of 310.43 g/mol. The compound~~ is ~~characterized by its high affinity for the~~ [[~~progesterone receptor~~]]~~, which contributes to its effectiveness~~ in ~~preventing ovulation~~.

	=== ~~Mechanism of Action~~ ===		=== Pharmacology ===
	Gestodene works primarily by inhibiting [[ovulation]]~~. It achieves this by suppressing~~ the ~~secretion of~~ [[~~gonadotropins~~]] ~~from~~ the [[~~pituitary gland~~]], ~~specifically~~ [[~~luteinizing hormone~~]] ~~(LH) and~~ [[~~follicle-stimulating~~ hormone]] (~~FSH~~)~~. This suppression prevents the mid-cycle~~ surge ~~of LH~~, ~~which is necessary for~~ ovulation. Additionally, ~~gestodene induces changes in~~ the [[~~endometrium~~]] ~~that make~~ it ~~less suitable~~ for [[~~implantation~~]] ~~and thickens the [[cervical mucus]], hindering sperm penetration~~.
			Gestodene is known for its high [[progestogenic]] activity and low [[androgenic]] activity, making it a preferred choice in contraceptive formulations. It works primarily by inhibiting [[ovulation]] and altering the [[endometrium]] to prevent [[implantation (human embryo)\|implantation]].

			==== Mechanism of Action ====

			Gestodene binds to the [[progesterone receptor]] in the body, mimicking the effects of natural [[progesterone]]. This leads to suppression of the [[luteinizing hormone]] (LH) surge, thereby preventing ovulation. Additionally, it increases the viscosity of [[cervical mucus]], making it more difficult for [[sperm]] to penetrate.

	=== Clinical Use ===		=== Clinical Use ===
	Gestodene is used in ~~various formulations of combined oral contraceptives~~. It is often ~~combined~~ with [[~~ethinylestradiol~~]], ~~a synthetic estrogen~~, ~~to enhance contraceptive efficacy. The typical dosage in contraceptive pills ranges from 60 to 75 micrograms of gestodene, combined with 20 to 30 micrograms of ethinylestradiol~~.
			Gestodene is primarily used in [[contraception]]. It is available in various formulations, often in combination with ethinylestradiol. These combinations are used to prevent [[pregnancy]] and can also regulate [[menstrual cycle\|menstrual cycles]], reduce [[menstrual pain]], and treat [[acne vulgaris\|acne]].

	=== Side Effects ===		=== Side Effects ===
	Like other hormonal contraceptives, gestodene-containing pills may cause side effects. Common side effects include [[nausea]], [[headache]], [[breast tenderness]], and [[mood changes]]. Rare but serious side effects include an increased risk of [[venous thromboembolism]] and [[myocardial infarction]], particularly in smokers and women over 35 years of age.

	=== ~~Advantages~~ ===		Common side effects of gestodene include [[nausea]], [[headache]], [[breast tenderness]], and [[mood changes]]. As with other hormonal contraceptives, there is a small increased risk of [[venous thromboembolism]] (VTE).
	Gestodene is ~~favored for its minimal androgenic effects, which reduces the risk~~ of ~~side effects~~ such as [[~~acne~~]] ~~and~~ [[~~hirsutism~~]]~~. Its high progestational activity allows for lower doses~~, which ~~can reduce the incidence of side effects associated with higher hormone levels~~.
			[[File:Gestodeno3D.png\|thumb\|left\|3D model of Gestodene]]

			=== Chemistry ===

			Gestodene is a derivative of [[19-nortestosterone]] and is structurally related to other progestins such as [[levonorgestrel]]. It is characterized by the presence of a [[17α-ethynyl group]], which is crucial for its progestogenic activity.

	=== ~~Pharmacokinetics~~ ===		=== History ===
	Gestodene is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It is extensively metabolized in the liver and excreted primarily in the urine. The elimination half-life of gestodene is approximately 12 to 14 hours.

	~~=== Images ===~~		Gestodene was developed in the 1980s and introduced for medical use in the early 1990s. It was part of the development of third-generation progestins aimed at reducing the androgenic side effects associated with earlier progestins.
	~~[[File:Gestodene_structure~~.~~png\|thumb\|right\|Chemical structure~~ of ~~gestodene]]~~

	=== Related Pages ===		== Related Pages ==
	* [[Progestogen]]		* [[Progestogen]]
	* [[Combined oral contraceptive pill]]		* [[Combined oral contraceptive pill]]
	* [[Ethinylestradiol]]		* [[Ethinylestradiol]]
	* [[~~Hormonal contraception~~]]		* [[Venous thromboembolism]]

	{{Hormonal ~~contraception~~}}		{{Hormonal contraceptives}}

	~~[[Category:Contraceptives]]~~
	[[Category:Progestogens]]		[[Category:Progestogens]]
			[[Category:Contraception]]

Prab: CSV import

2025-02-18T17:32:25Z

CSV import

← Older revision		Revision as of 17:32, 18 February 2025
Line 1:		Line 1:
	~~'''~~Gestodene~~''' is a [[progestogen]] hormonal contraceptive. Products containing gestodene include [[Meliane]], [[Gynera]] and [[Minesse]].~~		== Gestodene ==

	~~==Pharmacology==~~		'''Gestodene''' is a synthetic [[progestogen]] used in [[hormonal contraception]]. It is a third-generation progestin, which is often combined with [[estrogen]]s in [[combined oral contraceptive pill]]s. Gestodene is known for its high progestational activity and low androgenic activity, making it a popular choice in contraceptive formulations.
	Gestodene is a [[~~progestin~~]]~~, or a synthetic progestogen, and hence is an agonist of the~~ [[~~progesterone receptor~~]]~~, the biological target of progestogens like progesterone~~. It ~~has weak~~ [[~~androgen~~]]~~ic and~~ [[~~glucocorticoid~~]] activity and ~~no other important hormonal~~ activity.

	==~~Chemistry~~==		=== Chemical Properties ===
	Gestodene~~, also known as 17α-ethynyl-18-methyl-19-nor-δ15-testosterone,~~ is ~~a synthetic [[estrane]] steroid and~~ a derivative of [[~~testosterone~~]]. It ~~is more specifically~~ a ~~derivative~~ of [[~~norethisterone~~]] ~~(17α-ethynyl-19-nortestosterone) and is a member of the gonane (18-methylestrane) subgroup of the 19-nortestosterone family of progestins~~.		Gestodene is a derivative of [[19-nortestosterone]], which is a common structural basis for many synthetic progestins. It has the chemical formula C21H26O2 and a molecular weight of 310.43 g/mol. The compound is characterized by its high affinity for the [[progesterone receptor]], which contributes to its effectiveness in preventing ovulation.

	==~~History~~==		=== Mechanism of Action ===
	Gestodene ~~was patented in 1975 and introduced for medical use~~, specifically ~~in birth control pills~~, ~~in 1987~~. ~~It was introduced~~ in the ~~United States under~~ the ~~brand name Femodene in 1992~~.		Gestodene works primarily by inhibiting [[ovulation]]. It achieves this by suppressing the secretion of [[gonadotropins]] from the [[pituitary gland]], specifically [[luteinizing hormone]] (LH) and [[follicle-stimulating hormone]] (FSH). This suppression prevents the mid-cycle surge of LH, which is necessary for ovulation. Additionally, gestodene induces changes in the [[endometrium]] that make it less suitable for [[implantation]] and thickens the [[cervical mucus]], hindering sperm penetration.

	==~~Society and culture~~==		=== Clinical Use ===
	Gestodene is ~~marketed widely throughout the world~~. It is ~~available as a~~ combined ~~birth control pill in combination~~ with ~~the~~ [[~~estrogen~~]] ~~ethinylestradiol under~~ a ~~multitude~~ of ~~brand names~~.		Gestodene is used in various formulations of combined oral contraceptives. It is often combined with [[ethinylestradiol]], a synthetic estrogen, to enhance contraceptive efficacy. The typical dosage in contraceptive pills ranges from 60 to 75 micrograms of gestodene, combined with 20 to 30 micrograms of ethinylestradiol.

	==~~See also~~==		=== Side Effects ===
	* [[~~List of progestogens~~]]		Like other hormonal contraceptives, gestodene-containing pills may cause side effects. Common side effects include [[nausea]], [[headache]], [[breast tenderness]], and [[mood changes]]. Rare but serious side effects include an increased risk of [[venous thromboembolism]] and [[myocardial infarction]], particularly in smokers and women over 35 years of age.
	* [[~~List of progestogen esters~~]]
	* [[~~Progestogen-only pill~~]]
	* [[~~Progestin-only birth control~~]]

	==~~References~~==		=== Advantages ===
	~~<references />~~		Gestodene is favored for its minimal androgenic effects, which reduces the risk of side effects such as [[acne]] and [[hirsutism]]. Its high progestational activity allows for lower doses, which can reduce the incidence of side effects associated with higher hormone levels.

	~~{{stub}}~~		=== Pharmacokinetics ===
			Gestodene is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It is extensively metabolized in the liver and excreted primarily in the urine. The elimination half-life of gestodene is approximately 12 to 14 hours.

			=== Images ===
			[[File:Gestodene_structure.png\|thumb\|right\|Chemical structure of gestodene]]

			=== Related Pages ===
			* [[Progestogen]]
			* [[Combined oral contraceptive pill]]
			* [[Ethinylestradiol]]
			* [[Hormonal contraception]]

			{{Hormonal contraception}}

			[[Category:Contraceptives]]
	[[Category:Progestogens]]		[[Category:Progestogens]]
	~~[[Category:Contraception]]~~
	~~[[Category:Pharmacology]]~~
	~~[[Category:Chemistry]]~~
	~~[[Category:History of medicine]]~~
	~~[[Category:Society and culture]]~~
	~~<gallery>~~
	~~Gestodene~~
	~~File:Gestodene.svg\|Chemical structure of Gestodene~~
	~~File:Gestodeno3D.png\|3D model of Gestodene~~
	~~</gallery>~~

Prab: CSV import

2025-02-17T02:01:57Z

CSV import

← Older revision		Revision as of 02:01, 17 February 2025
Line 30:		Line 30:
	[[Category:History of medicine]]		[[Category:History of medicine]]
	[[Category:Society and culture]]		[[Category:Society and culture]]
			<gallery>
			Gestodene
			File:Gestodene.svg\|Chemical structure of Gestodene
			File:Gestodeno3D.png\|3D model of Gestodene
			</gallery>

Prab: CSV import

2024-02-22T03:12:07Z

CSV import

New page

'''Gestodene''' is a [[progestogen]] hormonal contraceptive. Products containing gestodene include [[Meliane]], [[Gynera]] and [[Minesse]].

==Pharmacology==
Gestodene is a [[progestin]], or a synthetic progestogen, and hence is an agonist of the [[progesterone receptor]], the biological target of progestogens like progesterone. It has weak [[androgen]]ic and [[glucocorticoid]] activity and no other important hormonal activity.

==Chemistry==
Gestodene, also known as 17α-ethynyl-18-methyl-19-nor-δ15-testosterone, is a synthetic [[estrane]] steroid and a derivative of [[testosterone]]. It is more specifically a derivative of [[norethisterone]] (17α-ethynyl-19-nortestosterone) and is a member of the gonane (18-methylestrane) subgroup of the 19-nortestosterone family of progestins.

==History==
Gestodene was patented in 1975 and introduced for medical use, specifically in birth control pills, in 1987. It was introduced in the United States under the brand name Femodene in 1992.

==Society and culture==
Gestodene is marketed widely throughout the world. It is available as a combined birth control pill in combination with the [[estrogen]] ethinylestradiol under a multitude of brand names.

==See also==
* [[List of progestogens]]
* [[List of progestogen esters]]
* [[Progestogen-only pill]]
* [[Progestin-only birth control]]

==References==
<references />

{{stub}}

[[Category:Progestogens]]
[[Category:Contraception]]
[[Category:Pharmacology]]
[[Category:Chemistry]]
[[Category:History of medicine]]
[[Category:Society and culture]]