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'''GLUT1''' or '''Glucose transporter 1''' is a [[protein]] that in humans is encoded by the SLC2A1 [[gene]]. GLUT1 facilitates the transport of [[glucose]] across the [[plasma membranes]] of [[mammal]]ian cells.

== Structure ==
GLUT1 is a member of a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. The GLUT1 protein is encoded by the SLC2A1 gene and is made up of 492 [[amino acids]]. It has a molecular weight of approximately 54 kDa.

== Function ==
GLUT1 is responsible for the low-level of basal glucose uptake required to sustain respiration in all cells. It is also a primary glucose transporter in the [[blood-brain barrier]] and it is responsible for glucose transport into the [[brain]].

== Clinical significance ==
Mutations in the SLC2A1 gene that affect the function of GLUT1 are responsible for GLUT1 deficiency syndrome. This syndrome is characterized by a variety of conditions including [[epilepsy]], [[developmental delay]], [[movement disorder]], and [[microcephaly]].

== See also ==
* [[GLUT]]
* [[Glucose transporter]]
* [[SLC2A1]]
* [[GLUT1 deficiency syndrome]]

== References ==
<references />

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Medical genetics]]
[[Category:Neurology]]
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GLUT1 - Revision history

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