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← Older revision		Revision as of 10:57, 18 February 2025
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	[[Category:Neurotransmitter receptors]]		[[Category:Neurotransmitter receptors]]
	[[Category:GABA]]		[[Category:GABA]]
			<gallery>
			File:Fig-GABAA_receptor.png\|GABAA receptor structure
			File:GABAA_receptor_schematic.png\|Schematic of GABAA receptor
			File:GABAA-receptor-protein-example-en.svg\|GABAA receptor protein example
			File:6x3v_GABAA-Rezeptorstruktur.png\|GABAA receptor structure
			File:GABAa_receptor.gif\|GABAA receptor
			File:6X3Z_GABAAR_GABA.png\|GABAA receptor with GABA
			</gallery>

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2024-02-28T19:52:04Z

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'''GABAA receptor''' is a type of [[protein]] that responds to the neurotransmitter [[gamma-aminobutyric acid]] (GABA), which is the chief inhibitory compound in the mature vertebrate central nervous system. GABAA receptors are members of the [[ligand-gated ion channel]] superfamily.

== Structure ==

The GABAA receptor is a multimeric [[transmembrane receptor]] that consists of five subunits arranged around a central pore. Each subunit comprises four transmembrane domains with both the N- and C-terminus located extracellularly. The receptor sits in the [[membrane]] of its neuron, usually localized at a [[synapse]], postsynaptically.

== Function ==

GABAA receptors occur in all organisms that have a nervous system. To a limited extent the receptors can be found in non-neuronal tissues. Due to their wide distribution within the nervous system of mammals they play a role in virtually all brain functions.

When an action potential reaches the [[neuron]] at the synapse, it causes or inhibits the release of GABA into the synapse. GABA then binds to GABAA receptors on the postsynaptic neuron and causes an influx of negative (chloride) ions into the neuron, making the postsynaptic membrane potential more negative, and thus inhibits the neuron from firing an action potential.

== Pharmacology ==

GABAA receptors are the targets of several classes of drugs, including [[benzodiazepines]], [[barbiturates]], and [[alcohols]]. These drugs bind to the GABAA receptor at distinct allosteric binding sites which are not the same as GABA itself and also modulate the receptor's activation and desensitization kinetics.

== See also ==
* [[GABAB receptor]]
* [[GABAC receptor]]
* [[Neurotransmitter]]

== References ==
<references />

{{Neuroscience-stub}}
[[Category:G protein-coupled receptors]]
[[Category:Ionotropic receptors]]
[[Category:Neurotransmitter receptors]]
[[Category:GABA]]

GABAA receptor - Revision history

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