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	[[Category:Microsporidiosis treatments]]		[[Category:Microsporidiosis treatments]]
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			File:Fumagillin structure.svg\|Fumagillin
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	~~[[File:~~Fumagillin~~.png\|thumb~~\|~~{{PAGENAME}}]]~~<br>~~'''Fumagillin''' is an [[antibiotic]] and [[antineoplastic]] compound derived from the fungus ''[[Aspergillus fumigatus]]''~~. It was first isolated in 1949 by A. W. Johnson and colleagues, who were studying the fungus as a potential source of new antibiotics. Fumagillin has since been found to have a broad range of biological activities, including anti-~~inflammatory, anti~~-~~angiogenic, and anti~~-~~tumor effects.~~		{{Infobox drug
			\| name = Fumagillin
			\| image = <!-- Image of the chemical structure -->
			\| width =
			\| alt =
			\| caption =
			\| pronounce =
			\| tradename =
			\| Drugs.com =
			\| MedlinePlus =
			\| pregnancy_AU =
			\| pregnancy_US =
			\| legal_AU =
			\| legal_CA =
			\| legal_UK =
			\| legal_US =
			\| legal_status =
			\| routes_of_administration =
			\| bioavailability =
			\| protein_bound =
			\| metabolism =
			\| elimination_half-life =
			\| excretion =
			\| CAS_number = 23110-15-8
			\| ATC_prefix =
			\| ATC_suffix =
			\| PubChem = 5284447
			\| DrugBank = DB04838
			\| ChemSpiderID = 4445360
			\| UNII = 0T793ZC2AR
			\| KEGG = D04197
			\| ChEBI = 5127
			\| ChEMBL = 1201684
			\| synonyms =
			}}

	~~== History ==~~		'''Fumagillin''' is a [[natural product]] originally isolated from the [[fungus]] ''[[Aspergillus fumigatus]]''. It is a complex [[organic compound]] that has been studied for its potential [[antimicrobial]] and [[antiparasitic]] properties. Fumagillin is particularly noted for its activity against [[microsporidia]], a group of [[spore-forming unicellular parasites]] that can cause disease in [[immunocompromised]] individuals.

	Fumagillin ~~was first isolated from ''~~[[~~Aspergillus fumigatus~~]]'' in ~~1949~~. The ~~discovery was part~~ of a ~~larger effort to identify new antibiotics from fungi. The compound was named after~~ the ~~fungus from which it was derived~~.		==Mechanism of Action==
			Fumagillin exerts its effects by inhibiting the enzyme [[methionine aminopeptidase 2]] (MetAP2). This inhibition disrupts the [[protein synthesis]] in [[microsporidia]], leading to their death. The specific targeting of MetAP2 makes fumagillin a valuable tool in the treatment of microsporidial infections.

	== ~~Biological activity~~ ==		==Medical Uses==
			Fumagillin has been used in the treatment of [[microsporidiosis]], particularly in patients with [[HIV/AIDS]] who are more susceptible to these infections. It has also been explored for its potential use in treating [[intestinal microsporidiosis]] and other related conditions.

	~~Fumagillin has a broad range of biological activities. It is a potent inhibitor~~ of [[~~angiogenesis~~]], ~~the process by which new blood vessels form~~. ~~This anti-angiogenic activity is thought to contribute to~~ fumagillin~~'s anti-tumor~~ effects~~. Fumagillin also has anti~~-~~inflammatory properties and has been shown to inhibit the growth of certain parasites~~.		==Side Effects==
			The use of fumagillin can be associated with several side effects, including [[gastrointestinal disturbances]], [[hepatotoxicity]], and [[bone marrow suppression]]. Patients receiving fumagillin should be monitored for these adverse effects, especially if they are on long-term therapy.

	== ~~Medical uses~~ ==		==Research and Development==
			Research is ongoing to develop fumagillin analogs with improved efficacy and reduced toxicity. These efforts aim to enhance the therapeutic potential of fumagillin while minimizing its side effects.

	Fumagillin has been used in the treatment of [[microsporidiosis]], a parasitic infection that can cause diarrhea and wasting in people with weakened immune systems. It has also been investigated for potential use in cancer therapy, due to its anti-angiogenic and anti-tumor properties.		==See Also==
			* [[Antimicrobial agents]]
	== ~~Pharmacology~~ ==		* [[Microsporidiosis]]
			* [[Aspergillus fumigatus]]
	~~Fumagillin exerts its effects by binding to and inhibiting the enzyme~~ [[~~methionine aminopeptidase 2~~]] ~~(MetAP2). MetAP2 is involved in the regulation of angiogenesis and inflammation, among other processes.~~

	~~== Safety ==~~

	~~Like all drugs, fumagillin has potential side effects. These can include nausea, vomiting, and diarrhea. More serious side effects, such as liver damage, have also been reported.~~

	== ~~See also~~ ==		==References==
			{{Reflist}}

	* [[Aspergillus fumigatus]]		==External Links==
	* [~~[Antibiotics]~~]		* [https://www.drugbank.ca/drugs/DB04838 DrugBank: Fumagillin]
	* [~~[Antineoplastic]]~~		* [https://pubchem.ncbi.nlm.nih.gov/compound/5284447 PubChem: Fumagillin]
	* [[Microsporidiosis]]

	[[Category:~~Antibiotics~~]]		{{Drugs}}
	[[Category:~~Antineoplastic drugs~~]]		{{Antimicrobials}}
	[[Category:~~Pharmacology~~]]		[[Category:Antimicrobial agents]]
	~~{{Antibiotics}}~~		[[Category:Antiparasitic agents]]
	~~{{Antineoplastic drugs}}~~		[[Category:Natural products]]
	~~{{Pharmacology-stub}}~~		[[Category:Aspergillus]]
			[[Category:Microsporidiosis treatments]]

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New page

[[File:Fumagillin.png|thumb|{{PAGENAME}}]]<br>'''Fumagillin''' is an [[antibiotic]] and [[antineoplastic]] compound derived from the fungus ''[[Aspergillus fumigatus]]''. It was first isolated in 1949 by A. W. Johnson and colleagues, who were studying the fungus as a potential source of new antibiotics. Fumagillin has since been found to have a broad range of biological activities, including anti-inflammatory, anti-angiogenic, and anti-tumor effects.

== History ==

Fumagillin was first isolated from ''[[Aspergillus fumigatus]]'' in 1949. The discovery was part of a larger effort to identify new antibiotics from fungi. The compound was named after the fungus from which it was derived.

== Biological activity ==

Fumagillin has a broad range of biological activities. It is a potent inhibitor of [[angiogenesis]], the process by which new blood vessels form. This anti-angiogenic activity is thought to contribute to fumagillin's anti-tumor effects. Fumagillin also has anti-inflammatory properties and has been shown to inhibit the growth of certain parasites.

== Medical uses ==

Fumagillin has been used in the treatment of [[microsporidiosis]], a parasitic infection that can cause diarrhea and wasting in people with weakened immune systems. It has also been investigated for potential use in cancer therapy, due to its anti-angiogenic and anti-tumor properties.

== Pharmacology ==

Fumagillin exerts its effects by binding to and inhibiting the enzyme [[methionine aminopeptidase 2]] (MetAP2). MetAP2 is involved in the regulation of angiogenesis and inflammation, among other processes.

== Safety ==

Like all drugs, fumagillin has potential side effects. These can include nausea, vomiting, and diarrhea. More serious side effects, such as liver damage, have also been reported.

== See also ==

* [[Aspergillus fumigatus]]
* [[Antibiotics]]
* [[Antineoplastic]]
* [[Microsporidiosis]]

[[Category:Antibiotics]]
[[Category:Antineoplastic drugs]]
[[Category:Pharmacology]]
{{Antibiotics}}
{{Antineoplastic drugs}}
{{Pharmacology-stub}}

Fumagillin - Revision history

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