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'''Free base''' refers to a [[base (chemistry)|base]] that has not been neutralized by an [[acid (chemistry)|acid]]. This term is often used in the context of [[organic chemistry]], where it can refer to the basic form of a [[chemical compound]] that has not reacted with an acid to form a [[salt (chemistry)|salt]]. Free bases are often more reactive than their corresponding salts, and they can be converted into salts by reaction with an appropriate acid.

==Chemistry==

In [[chemistry]], a free base is a compound that can accept [[proton]]s from an acid. This is in contrast to a salt, which is formed when a base reacts with an acid and accepts a proton. The term "free base" is often used to refer to the unprotonated form of a compound, which is typically more reactive than the protonated form.

Free bases can be formed from a variety of compounds, including [[amine]]s, [[alkaloid]]s, and other nitrogen-containing compounds. They are often used in chemical reactions that require a basic environment, such as [[nucleophilic substitution]] reactions and [[elimination reaction]]s.

==Pharmacology==

In [[pharmacology]], the term "free base" is often used to refer to the basic form of a drug that has not been converted into a salt. Many drugs are administered as salts because they are more stable and easier to handle in this form. However, the free base form of a drug can often be more potent, because it is more readily absorbed by the body.

For example, [[cocaine]] is often used in its free base form, known as "crack" cocaine. This form of the drug is more potent and faster-acting than the salt form, but it is also more dangerous because it can be more easily overdosed.

==See also==

* [[Acid-base reaction theories]]
* [[Base (chemistry)]]
* [[Salt (chemistry)]]

==References==

{{reflist}}

[[Category:Chemistry]]
[[Category:Pharmacology]]
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{{pharma-stub}}

Free base - Revision history

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