Prab: CSV import

2025-02-18T04:18:08Z

CSV import

← Older revision		Revision as of 04:18, 18 February 2025
Line 18:		Line 18:
	[[Category:Oncology]]		[[Category:Oncology]]
	{{bio-stub}}		{{bio-stub}}
			<gallery>
			File:Brainsci-10-00762-g004-550.png\|Folate receptor 1
			File:Identification_of_ovarian_cancer_metastases_using_fluorescence_imaging_of_folate_receptor_alpha.jpg\|Identification of ovarian cancer metastases using fluorescence imaging of folate receptor alpha
			</gallery>

Prab: CSV import

2024-03-30T04:08:57Z

CSV import

New page

'''Folate Receptor 1 (FOLR1)''' is a [[protein]] that in humans is encoded by the ''FOLR1'' [[gene]]. It is a member of the folate receptor (FR) family, which also includes [[Folate Receptor 2 (FOLR2)|Folate Receptor 2 (FOLR2)]] and [[Folate Receptor 3 (FOLR3)|Folate Receptor 3 (FOLR3)]]. Folate receptors are involved in the cellular uptake of [[folate]], a [[vitamin]] essential for numerous bodily functions, including [[DNA synthesis]] and repair, [[cell division]], and [[amino acid synthesis]]. Folate Receptor 1 is particularly important in mediating the uptake of folate in tissues with high metabolic demand such as in the [[placenta]] and in various [[cancer]] cells.

==Function==
Folate Receptor 1 binds to folate and reduced folic acid derivatives, facilitating their transport across the [[cell membrane]] through a process known as receptor-mediated [[endocytosis]]. This receptor is attached to the cell membrane by a [[glycosylphosphatidylinositol]] (GPI) anchor, which allows it to capture folate from the extracellular environment and deliver it into the cell. The high affinity of Folate Receptor 1 for folate makes it a critical component in maintaining folate homeostasis, especially in situations where folate demand is increased or in tissues with limited access to folate.

==Clinical Significance==
The expression of Folate Receptor 1 is elevated in several types of cancers, including [[ovarian cancer]], [[breast cancer]], and [[lung cancer]], making it a potential target for [[cancer therapy]]. Drugs and [[immunotherapy|immunotherapeutic agents]] targeting Folate Receptor 1 are being developed to deliver toxic agents specifically to cancer cells, minimizing damage to normal tissues. Additionally, alterations in the expression or function of Folate Receptor 1 have been implicated in various diseases and conditions, including [[neural tube defects]] and [[autoimmune diseases]], highlighting its importance in human health and disease.

==Genetics==
The ''FOLR1'' gene is located on [[chromosome]] 11 in humans. Variants and mutations in this gene can affect the expression and function of Folate Receptor 1, potentially leading to altered folate uptake and associated health issues. Genetic studies are ongoing to better understand the role of ''FOLR1'' gene variants in disease and to develop personalized medical approaches based on an individual's genetic makeup.

==Research Directions==
Research on Folate Receptor 1 continues to explore its role in health and disease, with a particular focus on its potential as a therapeutic target in cancer. Studies are also investigating the impact of genetic variations in the ''FOLR1'' gene on the risk of developing certain diseases and on the efficacy of folate-based therapies. Understanding the molecular mechanisms regulating the expression and function of Folate Receptor 1 is crucial for developing new and more effective treatments for diseases associated with folate metabolism.

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Cell biology]]
[[Category:Oncology]]
{{bio-stub}}

Folate receptor 1 - Revision history

Prab: CSV import

Prab: CSV import