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2025-02-13T03:51:42Z

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← Older revision		Revision as of 03:51, 13 February 2025
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	{{~~intro~~}}		{{Short description\|A nonsteroidal anti-inflammatory drug}}
			{{Drugbox}}

	Flurbiprofen is a nonsteroidal ~~antiinflammatory~~ drug ([[~~NSAID~~]]~~) used in treatment of mild-to-moderate~~ pain and ~~symptoms~~ of ~~chronic arthritis~~.		==Overview==
			[[File:Flurbiprofen.svg\|thumb\|right\|Chemical structure of Flurbiprofen]]
			'''Flurbiprofen''' is a [[nonsteroidal anti-inflammatory drug]] (NSAID) used to treat pain and inflammation. It is commonly prescribed for conditions such as [[arthritis]], [[dental pain]], and [[postoperative pain]]. Flurbiprofen works by inhibiting the production of [[prostaglandins]], which are chemicals in the body responsible for inflammation and pain.

	~~{{livtox}}~~		==Pharmacology==
	Flurbiprofen ~~has been linked to~~ a ~~low rate~~ of ~~serum enzyme elevations during therapy~~ and ~~to rare instances~~ of ~~clinically apparent acute liver injury~~.		Flurbiprofen is a member of the [[propionic acid]] class of NSAIDs, which also includes drugs like [[ibuprofen]] and [[naproxen]]. It is available in both oral and topical formulations. The drug is absorbed in the gastrointestinal tract and is metabolized in the [[liver]]. Its mechanism of action involves the inhibition of the [[cyclooxygenase]] (COX) enzymes, specifically COX-1 and COX-2, which are involved in the synthesis of prostaglandins.

	~~{{moa}}~~		==Medical Uses==
	Flurbiprofen ~~(flur" bi proe' fen) belongs~~ to ~~the propionic acid derivative class~~ of [[~~NSAIDs~~]]~~, similar to fenoprofen, naproxen~~ and ~~ibuprofen. Like other~~ [[~~NSAIDs~~]]~~, flurbiprofen is a cyclo-oxygenase~~ (~~Cox-1 and -2~~) ~~inhibitor that blocks the formation of prostaglandins that are important in~~ pain ~~and inflammatory pathways. Flurbiprofen has analgesic as well as antipyretic and antiinflammatory activities. Flurbiprofen was approved in the United States in 1988.~~		Flurbiprofen is used to manage various types of pain and inflammation. It is effective in treating:
			* [[Osteoarthritis]] and [[rheumatoid arthritis]]
			* [[Ankylosing spondylitis]]
			* [[Dysmenorrhea]] (painful menstruation)
			* [[Migraine]]
			* [[Postoperative pain]]

	~~{{use}}~~		==Side Effects==
	~~Current indications~~ include chronic joint pain due to osteoarthritis and rheumatoid arthritis, as well as mild-to-moderate acute pain. The recommended dose in adults with chronic arthritis is 50 to 100 mg two to four times daily, with a maximum dose of 300 mg daily. Flurbiprofen is available by prescription in the form of capsules or tablets of 50 and 100 mg in both generic and trade formulations (Ansaid).		Common side effects of flurbiprofen include:
			* [[Gastrointestinal discomfort]]
			* [[Nausea]]
			* [[Dizziness]]
			* [[Headache]]

	~~{{se}}~~		Serious side effects may include:
	~~As with other [[NSAIDs]], flurbiprofen is generally well tolerated, but~~ side effects ~~can~~ include [[~~headache~~]]~~, dizziness,~~ [[~~somnolence~~]]~~, gastrointestinal upset,~~ [[~~nausea~~]], [[~~abdominal discomfort~~]]~~, [[diarrhea]], edema and [[hypersensitivity]] reactions.~~		* [[Gastrointestinal bleeding]]
			* [[Kidney damage]]
			* [[Liver damage]]
			* [[Allergic reactions]]

	~~{{nsaids}}~~		==Contraindications==
	~~{{coststubd}}~~		Flurbiprofen should not be used in individuals with:
			* [[Hypersensitivity]] to NSAIDs
			* [[Peptic ulcer disease]]
			* [[Severe heart failure]]
			* [[Severe liver impairment]]

			==Interactions==
			Flurbiprofen may interact with other medications, including:
			* [[Anticoagulants]] such as [[warfarin]]
			* [[Antihypertensives]]
			* [[Diuretics]]
			* [[Lithium]]

			==Related pages==
			* [[Nonsteroidal anti-inflammatory drug]]
			* [[Ibuprofen]]
			* [[Naproxen]]
			* [[Cyclooxygenase]]

			[[Category:Nonsteroidal anti-inflammatory drugs]]

Prab at 13:00, 11 May 2019

2019-05-11T13:00:56Z

New page

{{intro}}

Flurbiprofen is a nonsteroidal antiinflammatory drug ([[NSAID]]) used in treatment of mild-to-moderate pain and symptoms of chronic arthritis.

{{livtox}}
Flurbiprofen has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.

{{moa}}
Flurbiprofen (flur" bi proe' fen) belongs to the propionic acid derivative class of [[NSAIDs]], similar to fenoprofen, naproxen and ibuprofen. Like other [[NSAIDs]], flurbiprofen is a cyclo-oxygenase (Cox-1 and -2) inhibitor that blocks the formation of prostaglandins that are important in pain and inflammatory pathways. Flurbiprofen has analgesic as well as antipyretic and antiinflammatory activities. Flurbiprofen was approved in the United States in 1988.

{{use}}
Current indications include chronic joint pain due to osteoarthritis and rheumatoid arthritis, as well as mild-to-moderate acute pain. The recommended dose in adults with chronic arthritis is 50 to 100 mg two to four times daily, with a maximum dose of 300 mg daily. Flurbiprofen is available by prescription in the form of capsules or tablets of 50 and 100 mg in both generic and trade formulations (Ansaid).

{{se}}
As with other [[NSAIDs]], flurbiprofen is generally well tolerated, but side effects can include [[headache]], dizziness, [[somnolence]], gastrointestinal upset, [[nausea]], [[abdominal discomfort]], [[diarrhea]], edema and [[hypersensitivity]] reactions.

{{nsaids}}
{{coststubd}}

Flurbiprofen - Revision history

Prab: CSV import

Prab at 13:00, 11 May 2019