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Fluorothymidine F-18 - Revision history
2026-04-26T12:29:02Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=Fluorothymidine_F-18&diff=6493878&oldid=prev
Prab at 21:55, 16 March 2025
2025-03-16T21:55:09Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:55, 16 March 2025</td>
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Prab
https://wikimd.org/index.php?title=Fluorothymidine_F-18&diff=6343785&oldid=prev
Prab: CSV import
2025-02-24T23:58:05Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:58, 24 February 2025</td>
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https://wikimd.org/index.php?title=Fluorothymidine_F-18&diff=6235223&oldid=prev
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2025-02-10T17:38:08Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:38, 10 February 2025</td>
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Prab
https://wikimd.org/index.php?title=Fluorothymidine_F-18&diff=5331916&oldid=prev
Prab: CSV import
2024-02-29T05:28:10Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Fluorothymidine F-18''' (also known as '''FLT F-18''' or '''18F-FLT''') is a [[radiopharmaceutical]] used in [[Positron Emission Tomography|positron emission tomography (PET)]] imaging. It is a [[fluorine-18]] labeled analogue of the [[nucleoside]] [[thymidine]], which is incorporated into the [[DNA]] of proliferating cells.<br />
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==Chemistry==<br />
Fluorothymidine F-18 is a [[fluorinated]] analogue of the nucleoside thymidine. The fluorine-18 atom replaces a hydrogen atom on the methyl group of thymidine. This modification allows the molecule to be detected by PET imaging, as fluorine-18 is a [[positron]] emitter.<br />
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==Pharmacology==<br />
Fluorothymidine F-18 is taken up by cells and phosphorylated by the enzyme [[thymidine kinase]] to form FLT-monophosphate. This molecule is then further phosphorylated to form FLT-diphosphate and FLT-triphosphate, which can be incorporated into DNA. The rate of FLT uptake and phosphorylation is proportional to the rate of cellular proliferation, making FLT F-18 a useful marker of tumor growth and response to therapy.<br />
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==Clinical Use==<br />
Fluorothymidine F-18 is used in PET imaging to assess tumor proliferation in patients with various types of cancer, including [[lung cancer]], [[breast cancer]], and [[brain tumors]]. It can also be used to monitor the response of tumors to [[chemotherapy]] and [[radiation therapy]]. In addition, FLT F-18 can be used to assess the proliferation of normal tissues, such as the bone marrow and lymphoid tissues.<br />
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==Safety and Side Effects==<br />
As with all radiopharmaceuticals, there is a risk of radiation exposure with the use of FLT F-18. However, the risk is generally low and is considered acceptable in the context of the potential benefits of the imaging procedure. Side effects are rare and typically mild, including allergic reactions and injection site reactions.<br />
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==See Also==<br />
* [[Positron Emission Tomography]]<br />
* [[Radiopharmaceutical]]<br />
* [[Thymidine kinase]]<br />
* [[Fluorine-18]]<br />
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[[Category:Radiopharmaceuticals]]<br />
[[Category:Medical imaging]]<br />
[[Category:Nuclear medicine]]<br />
[[Category:Oncology]]<br />
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