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<p><b>New page</b></p><div>[[File:Fluclotizolam.png|thumb|{{PAGENAME}}]]<br>'''Fluclotizolam''' is a [[thienotriazolodiazepine]] derivative which was first synthesized in 1979, but was never marketed. It has subsequently been sold as a [[designer drug]], first being definitively identified in 2017. <br />
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==Chemistry==<br />
Fluclotizolam is a thienotriazolodiazepine, which is a group of [[benzodiazepine]] analogs. The thienotriazolodiazepine core of fluclotizolam is a combination of a [[thiophene]] ring fused with a [[triazolodiazepine]] ring. This core structure is shared with a number of other benzodiazepine drugs, including [[etizolam]] and [[brotizolam]].<br />
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==Pharmacology==<br />
Like other benzodiazepines, fluclotizolam acts as a positive allosteric modulator of the [[GABA_A receptor]], enhancing the effects of the neurotransmitter [[GABA]]. This results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.<br />
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==Effects==<br />
The effects of fluclotizolam are similar to other benzodiazepines, such as anxiolysis, disinhibition, lethargy, muscle relaxation, and euphoria. However, due to its potency, it also has a high potential for abuse and can cause severe physical dependence and withdrawal symptoms.<br />
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==Legal Status==<br />
The legal status of fluclotizolam varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.<br />
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==See Also==<br />
* [[Designer drug]]<br />
* [[Benzodiazepine]]<br />
* [[Etizolam]]<br />
* [[Brotizolam]]<br />
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[[Category:Thienotriazolodiazepines]]<br />
[[Category:Designer drugs]]<br />
[[Category:GABA_A receptor positive allosteric modulators]]<br />
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{{GABAergics}}<br />
{{Sedatives}}<br />
{{Anxiolytics}}<br />
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