https://wikimd.org/index.php?action=history&feed=atom&title=Finasteride 2026-05-08T23:01:20Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Finasteride&diff=4960316&oldid=prev 2023-04-08T04:15:17Z

<p></p> <p><b>New page</b></p><div>Finasteride (fih-NAS-teh-ride) is a drug used to reduce the amount of male hormone (testosterone) produced by the body.<br /> [[File:Finasteride.svg|Finasteride|thumb]]<br /> {{intro}}<br /> Finasteride is a 5-alpha reductase inhibitor used to treat symptoms of [[benign prostatic hypertrophy]] and male pattern [[baldness]].<br /> {{livtox}}<br /> Finasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent, acute liver injury.<br /> {{moa}}<br /> Finasteride (fin as&#039; ter ide) was the first 5-alpha reductase inhibitor to be approved for use as therapy of symptomatic [[benign prostatic hypertrophy]] in the United States. Finasteride inhibits the steroid 5-alpha reductase, which blocks the conversion of testosterone to dihydrotestosterone, a form of the androgenic hormone that is important in the development and maintenance of prostatic hyperplasia. Serum dihydrotesterone levels are decreased by 70% to 90% by finasteride therapy with little effect on testosterone levels. Finasteride takes several months to have an effect on prostate size and symptoms of prostatic hypertrophy ([[urinary hesitancy]] and poor stream), unlike the alpha-1 adrenergic receptor blockers which have a more immediate effect. Finasteride also inhibits the steroid 5-alpha reductase present in skin, which led to its use in the therapy or prevention of male pattern [[baldness]].<br /> {{fda}}<br /> Finasteride was approved for use in the United States in 1992 and is available in 5 mg tablets generically and under the trade name Proscar for prostatic hypertrophy, and as 1 mg tablets under the name Propecia for male pattern [[baldness]].<br /> {{dose}}<br /> The recommended dose for therapy of prostatic hypertrophy is 5 mg once daily, and it generally requires 3 to 6 months before an effect is obtained and thereafter requires long term therapy. The dose of finasteride for male pattern [[baldness]] is 1 mg daily. It is not recommended as therapy for [[baldness]] in women.<br /> {{se}}<br /> Side effects are uncommon, but include a low rate of impotence and decreased [[libido]], [[gynecomastia]], [[dizziness]] and [[weakness]]. Finasteride also decreases serum [[PSA]] levels (~50%), which should be monitored during therapy.<br /> {{bph drugs}} <br /> {{coststubd}}<br /> {{Androgens and antiandrogens}}<br /> {{Drugs used in benign prostatic hypertrophy}}<br /> {{Other dermatological preparations}}<br /> {{Merck&amp;Co}}<br /> {{Portal bar | Medicine}}<br /> [[Category:5α-Reductase inhibitors]]<br /> [[Category:Androstanes]]<br /> [[Category:Merck &amp; Co. brands]]<br /> [[Category:Carboxamides]]<br /> [[Category:Hair loss medications]]<br /> [[Category:Hair removal]]<br /> [[Category:Delta-lactams]]<br /> [[Category:Teratogens]]<br /> [[Category:Tert-butyl compounds]]</div>

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