https://wikimd.org/index.php?action=history&feed=atom&title=FilgotinibFilgotinib - Revision history2026-05-12T01:15:21ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Filgotinib&diff=5368573&oldid=prevPrab: CSV import2024-03-06T04:09:01Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Filgotinib.png|thumb|{{PAGENAME}}]]<br>'''Filgotinib''' is a [[Janus kinase inhibitor]] developed by [[Gilead Sciences]] and [[Galapagos NV]] for the treatment of [[rheumatoid arthritis]], [[ulcerative colitis]], and [[Crohn's disease]]. It is a selective JAK1 inhibitor with IC50 of 10 nM, approximately 28-fold selective for JAK1 over JAK2.<br />
<br />
== History ==<br />
<br />
Filgotinib was initially developed by the Belgian company [[Galapagos NV]]. In 2015, [[Gilead Sciences]] acquired the rights to the drug for $2 billion. The drug was submitted for approval in the [[European Union]] (EU) and [[Japan]] in 2019, and was approved in the EU in September 2020 under the brand name Jyseleca.<br />
<br />
== Mechanism of Action ==<br />
<br />
Filgotinib is a [[Janus kinase inhibitor]], which works by blocking the action of one or more of a specific family of enzymes, interfering with the pathway that leads to inflammation. It is a selective JAK1 inhibitor, which means it primarily blocks the Janus kinase 1 (JAK1) enzyme.<br />
<br />
== Clinical Trials ==<br />
<br />
Several [[clinical trials]] have been conducted to evaluate the efficacy and safety of Filgotinib. These include Phase 2 and 3 trials for [[rheumatoid arthritis]], [[ulcerative colitis]], and [[Crohn's disease]]. The results have shown that Filgotinib is effective in reducing symptoms and improving quality of life in patients with these conditions.<br />
<br />
== Side Effects ==<br />
<br />
Common side effects of Filgotinib include [[nausea]], [[upper respiratory tract infection]], and [[urinary tract infection]]. Serious side effects may include serious infections, cancers, and blood clots.<br />
<br />
== See Also ==<br />
<br />
* [[Janus kinase inhibitor]]<br />
* [[Rheumatoid arthritis]]<br />
* [[Ulcerative colitis]]<br />
* [[Crohn's disease]]<br />
<br />
[[Category:Drugs]]<br />
[[Category:Pharmacology]]<br />
[[Category:Rheumatology]]<br />
[[Category:Gastroenterology]]<br />
<br />
{{Pharmacology-stub}}<br />
{{Rheumatology-stub}}<br />
{{Gastroenterology-stub}}</div>Prab