https://wikimd.com/index.php?action=history&feed=atom&title=Factor_XI Factor XI - Revision history 2026-04-21T07:43:12Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Factor_XI&diff=6533179&oldid=prev Prab at 17:07, 22 March 2025 2025-03-22T17:07:22Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:07, 22 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l26">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=Factor_XI&diff=5231601&oldid=prev Prab: CSV import 2024-02-23T03:43:25Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Factor XI&#039;&#039;&#039; or &#039;&#039;&#039;Plasma Thromboplastin Antecedent&#039;&#039;&#039; is the zymogen form of [[Factor XIa]], one of the enzymes of the [[coagulation cascade]]. It is part of the [[contact activation pathway]] and has an important role in both [[intrinsic]] and [[extrinsic coagulation pathway]]s.<br /> <br /> == Structure ==<br /> Factor XI is a dimer and each monomer is a polypeptide chain. The monomers are identical, each having a molecular weight of approximately 80,000. The chain is organized into 4 apple domains and a serine protease domain.<br /> <br /> == Function ==<br /> Factor XI is activated by [[Factor XIIa]] and/or [[Factor IX]], in a calcium-dependent manner, to Factor XIa. Factor XIa then activates [[Factor IX]] to Factor IXa, in the presence of calcium. This is the first step of the intrinsic pathway of coagulation.<br /> <br /> == Clinical significance ==<br /> Deficiency of Factor XI causes the rare [[Hemophilia C]]. It is less severe than [[Hemophilia A]] and [[Hemophilia B]]. Patients with Factor XI deficiency have a normal [[PT]] (Prothrombin Time) and aPTT (Activated Partial Thromboplastin Time) may or may not be prolonged.<br /> <br /> == See also ==<br /> * [[Coagulation]]<br /> * [[Hemophilia]]<br /> * [[Factor XI Deficiency]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> == External links ==<br /> * [https://www.wikimd.com/wiki/Factor_XI Factor XI] at WikiMD<br /> <br /> [[Category:Coagulation system]]<br /> [[Category:Blood]]<br /> [[Category:Hematology]]<br /> {{stub}}</div> Prab