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Factor VII - Revision history
2026-04-23T18:21:03Z
Revision history for this page on the wiki
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Prab at 17:07, 22 March 2025
2025-03-22T17:07:22Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:07, 22 March 2025</td>
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Prab
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Prab: CSV import
2025-03-17T11:55:29Z
<p>CSV import</p>
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Prab: CSV import
2025-02-10T17:08:35Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:08, 10 February 2025</td>
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Prab
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Prab: CSV import
2024-02-23T03:36:12Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Factor VII''' (also known as '''serum prothrombin conversion accelerator''' or '''proconvertin''') is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. The gene for Factor VII is located on chromosome 13 (13q34).<br />
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== Function ==<br />
Factor VII is produced in the liver and released into the bloodstream. When an injury occurs and bleeding begins, Factor VII is activated and begins the process of coagulation. Activated Factor VII (FVIIa) starts the coagulation cascade by binding to tissue factor (TF), which is exposed upon injury. The TF/FVIIa complex activates [[Factor IX]] and [[Factor X]], which further propagate the coagulation cascade.<br />
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== Deficiency ==<br />
A deficiency of Factor VII, known as [[Factor VII deficiency]], is a rare genetic disorder characterized by a lack of Factor VII. This can lead to a bleeding diathesis, with symptoms ranging from mild to severe bleeding. Treatment typically involves replacement therapy with recombinant Factor VII.<br />
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== Role in disease ==<br />
Factor VII is also involved in several diseases. High levels of Factor VII are associated with an increased risk of coronary heart disease. Additionally, Factor VII is used therapeutically in the treatment of hemophilia, a genetic disorder that impairs the body's ability to make blood clots.<br />
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== See also ==<br />
* [[Coagulation]]<br />
* [[Hemophilia]]<br />
* [[Factor VII deficiency]]<br />
* [[Factor IX]]<br />
* [[Factor X]]<br />
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== References ==<br />
<references /><br />
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{{stub}}<br />
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[[Category:Blood]]<br />
[[Category:Coagulation system]]<br />
[[Category:Genetic disorders]]<br />
[[Category:Medical terms]]<br />
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Prab