https://wikimd.org/index.php?action=history&feed=atom&title=Factor_DFactor D - Revision history2026-04-25T01:40:55ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Factor_D&diff=6313716&oldid=prevPrab: CSV import2025-02-18T02:01:52Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Factor_D&diff=5377597&oldid=prevPrab: CSV import2024-03-09T20:51:24Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Factor D''' is a protein that plays a crucial role in the [[alternative complement pathway]], one of the body's immune response mechanisms. It is part of the [[complement system]], a group of proteins that work together to destroy foreign cells, trigger inflammation, and perform other immune system functions.<br />
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== Structure ==<br />
Factor D is a single-chain [[polypeptide]] composed of 214 [[amino acids]]. It is synthesized in the liver and then released into the bloodstream, where it circulates as an inactive enzyme. The active form of Factor D is generated through the cleavage of a single peptide bond, a process that is catalyzed by [[Factor B]].<br />
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== Function ==<br />
Factor D is a [[serine protease]] that is essential for the activation of the alternative complement pathway. It cleaves Factor B, which is bound to [[C3b]], to generate the active enzyme [[C3 convertase]]. This enzyme then cleaves C3, the most abundant protein in the complement system, into C3a and C3b. C3b binds to the surface of foreign cells, marking them for destruction by [[phagocytes]].<br />
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== Clinical significance ==<br />
Deficiencies in Factor D can lead to an increased susceptibility to infections, particularly from bacteria and fungi. This is because the alternative complement pathway plays a key role in the body's defense against these types of pathogens. In addition, mutations in the gene that encodes Factor D have been associated with age-related [[macular degeneration]], a leading cause of blindness in older adults.<br />
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== See also ==<br />
* [[Complement system]]<br />
* [[Alternative complement pathway]]<br />
* [[Factor B]]<br />
* [[C3 convertase]]<br />
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== References ==<br />
<references /><br />
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[[Category:Proteins]]<br />
[[Category:Immune system]]<br />
[[Category:Complement system]]<br />
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