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	'''FOXO4''' is a ~~member~~ of the [[~~FOXO~~]] family of transcription factors, which ~~play a crucial role~~ in the regulation of [[gene expression]]~~. This protein is encoded by the FOXO4 gene in humans~~.
			{{Infobox protein
			\| name = Forkhead box protein O4
			\| symbol = FOXO4
			\| image = <!-- Image removed -->
			\| width =
			\| caption =
			\| HGNCid = 13875
			\| EntrezGene = 4303
			\| OMIM = 602342
			\| RefSeq = NM_005938
			\| UniProt = P98177
			\| PDB =
			\| ECnumber =
			\| Chromosome = X
			\| Arm = q
			\| Band = 13.1
			\| LocusSupplementaryData =
			}}

			'''Forkhead box protein O4''' ('''FOXO4''') is a [[protein]] that in humans is encoded by the '''FOXO4''' [[gene]]. This protein is part of the [[forkhead box]] (FOX) family of [[transcription factors]], which are involved in the regulation of [[gene expression]] related to [[cellular processes]] such as [[cell cycle]] control, [[apoptosis]], and [[metabolism]].

	== Function ==		== Function ==
	FOXO4 is ~~involved in~~ a ~~variety~~ of ~~biological processes~~, ~~including~~ [[~~cell cycle~~]] ~~regulation~~, [[~~apoptosis~~]], [[~~DNA damage repair~~]]~~, and~~ [[~~oxidative stress~~]] ~~response. It~~ acts as a ~~tumor suppressor by inhibiting cell proliferation~~ and ~~promoting cell death~~.		FOXO4 is a member of the O subclass of forkhead transcription factors, which play a critical role in the regulation of [[oxidative stress]] responses, [[longevity]], and [[tumor suppression]]. FOXO4 is known to be involved in the [[insulin signaling pathway]], where it acts as a downstream effector that can influence [[glucose metabolism]] and [[insulin sensitivity]].

	== ~~Structure~~ ==		== Clinical significance ==
	~~The~~ FOXO4 ~~protein consists of~~ a ~~highly conserved~~ [[~~forkhead box~~]] ~~domain, which is responsible for binding~~ to ~~specific~~ DNA ~~sequences in~~ the [[~~genome~~]]~~. This domain is flanked by two transactivation domains~~, which ~~are involved in the regulation of gene expression~~.		Alterations in FOXO4 activity have been associated with various [[diseases]], including [[cancer]] and [[diabetes mellitus]]. In [[cancer]], FOXO4 can function as a [[tumor suppressor]] by inducing [[cell cycle arrest]] and [[apoptosis]] in response to [[DNA damage]]. However, its activity can be inhibited by [[oncogenic]] signaling pathways, such as the [[PI3K/AKT pathway]], which leads to its [[phosphorylation]] and subsequent [[nuclear exclusion]].

	~~== Role in Disease ==~~		In the context of [[aging]], FOXO4 has been implicated in the regulation of [[cellular senescence]], a process that contributes to [[age-related diseases]]. Recent studies have explored the potential of targeting FOXO4 to selectively eliminate [[senescent cells]], thereby improving [[healthspan]] and [[lifespan]].
	~~Alterations in~~ the ~~function or expression~~ of ~~FOXO4 have been implicated in several diseases, including~~ [[~~cancer~~]], [[~~diabetes~~]], ~~and [[cardiovascular disease]]. In cancer, FOXO4 can act as~~ a ~~tumor suppressor, but its function can be inhibited by~~ [[~~oncogenic~~]] ~~signaling pathways~~. ~~In diabetes,~~ FOXO4 ~~can regulate~~ [[~~glucose metabolism~~]] ~~and [[insulin sensitivity]]. In cardiovascular disease~~, ~~FOXO4 can regulate the expression of genes involved in~~ [[~~cardiac hypertrophy~~]] and [[~~heart failure~~]].

	== ~~Research~~ ==		== Interactions ==
	~~Recent research has focused on the potential use of~~ FOXO4 ~~as a therapeutic target in various diseases~~. ~~For example~~, ~~a peptide targeting~~ FOXO4 ~~has been shown~~ to ~~selectively kill senescent cells, which could have implications for the treatment of~~ [[~~aging~~]] ~~and age~~-~~related diseases~~.		FOXO4 interacts with several other proteins to exert its functions. It can form complexes with [[14-3-3 proteins]], which regulate its subcellular localization and activity. Additionally, FOXO4 can interact with [[SMAD proteins]] to modulate [[transforming growth factor-beta]] (TGF-β) signaling.

	[[~~File:FOXO4 protein structure.jpg\|thumb\|right\|300px\|Structure of the FOXO4 protein. Image from Wikimedia Commons.~~]]		== See also ==
			* [[Forkhead box]]
			* [[Transcription factor]]
			* [[Insulin signaling pathway]]
			* [[Cellular senescence]]

	== ~~See Also~~ ==		== References ==
	* [[FOXO1]]		{{Reflist}}
	* [[FOXO3]]
	* [[FOXO6]]
	* [[Forkhead box proteins]]

	== ~~References~~ ==		== External links ==
	~~<references />~~		* {{GeneReviews\|FOXO4}}
			* {{OMIM\|602342}}

	[[Category:Transcription factors]]		[[Category:Transcription factors]]
			[[Category:Forkhead proteins]]
	[[Category:Human proteins]]		[[Category:Human proteins]]
	[[Category:Genes]]		[[Category:Genes on human chromosome X]]
	~~[[Category:FOXO]]~~

	~~{{medicine-stub}}~~
	~~{{biochemistry-stub}}~~

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'''FOXO4''' is a member of the [[FOXO]] family of transcription factors, which play a crucial role in the regulation of [[gene expression]]. This protein is encoded by the FOXO4 gene in humans.

== Function ==
FOXO4 is involved in a variety of biological processes, including [[cell cycle]] regulation, [[apoptosis]], [[DNA damage repair]], and [[oxidative stress]] response. It acts as a tumor suppressor by inhibiting cell proliferation and promoting cell death.

== Structure ==
The FOXO4 protein consists of a highly conserved [[forkhead box]] domain, which is responsible for binding to specific DNA sequences in the [[genome]]. This domain is flanked by two transactivation domains, which are involved in the regulation of gene expression.

== Role in Disease ==
Alterations in the function or expression of FOXO4 have been implicated in several diseases, including [[cancer]], [[diabetes]], and [[cardiovascular disease]]. In cancer, FOXO4 can act as a tumor suppressor, but its function can be inhibited by [[oncogenic]] signaling pathways. In diabetes, FOXO4 can regulate [[glucose metabolism]] and [[insulin sensitivity]]. In cardiovascular disease, FOXO4 can regulate the expression of genes involved in [[cardiac hypertrophy]] and [[heart failure]].

== Research ==
Recent research has focused on the potential use of FOXO4 as a therapeutic target in various diseases. For example, a peptide targeting FOXO4 has been shown to selectively kill senescent cells, which could have implications for the treatment of [[aging]] and age-related diseases.

[[File:FOXO4 protein structure.jpg|thumb|right|300px|Structure of the FOXO4 protein. Image from Wikimedia Commons.]]

== See Also ==
* [[FOXO1]]
* [[FOXO3]]
* [[FOXO6]]
* [[Forkhead box proteins]]

== References ==
<references />

[[Category:Transcription factors]]
[[Category:Human proteins]]
[[Category:Genes]]
[[Category:FOXO]]

{{medicine-stub}}
{{biochemistry-stub}}

FOXO4 - Revision history

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