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	'''FCGR2C''' or '''Fc gamma receptor IIc''' is a protein that in humans is encoded by the FCGR2C gene. It is a member of the [[Fc gamma receptor]] family, which are cell surface receptors found on certain cells in the immune system. These receptors play a key role in the immune response, including the process of [[phagocytosis]] and the release of [[cytokines]].

	== ~~Structure~~ ==		{{DISPLAYTITLE:FCGR2C}}
	~~The~~ FCGR2C ~~protein~~ is a ~~low affinity receptor for~~ the ~~Fc region of~~ [[~~immunoglobulin G~~]] ~~(IgG)~~. It is ~~structurally similar to other~~ Fc gamma ~~receptors~~, ~~consisting~~ of ~~two extracellular~~ [[~~immunoglobulin domain\|Ig-like domains~~]]~~, a transmembrane domain,~~ and ~~a cytoplasmic tail. The extracellular domains are responsible for binding to IgG, while~~ the ~~cytoplasmic tail is involved in signal transduction~~.		{{Infobox gene
			\| name = FCGR2C
			\| image = <!-- Image removed -->
			\| caption = <!-- Image caption removed -->
			\| HGNCid = 3617
			\| symbol = FCGR2C
			\| alt_symbols = IGFR2, CD32
			\| EntrezGene = 9103
			\| OMIM = 146790
			\| RefSeq = NM_001002274
			\| UniProt = Q9Y6R4
			\| chromosome = 1
			\| arm = q
			\| band = 23
			}}

			'''FCGR2C''' ('''Fc fragment of IgG receptor IIc''') is a [[gene]] that encodes a protein involved in the [[immune system]]'s response to [[pathogens]]. This gene is part of the [[Fc gamma receptor]] family, which plays a critical role in the [[phagocytosis]] of [[immune complexes]] and the regulation of [[antibody]] production.

	== Function ==		== Function ==
	FCGR2C ~~is involved in~~ a ~~variety~~ of ~~immune responses~~. ~~It can mediate phagocytosis,~~ the ~~process by which~~ cells ~~engulf~~ and ~~destroy foreign particles or pathogens~~. It ~~can also trigger~~ the ~~release~~ of ~~cytokines~~, ~~which~~ are ~~signaling molecules that regulate immune responses~~. ~~In addition,~~ FCGR2C ~~can activate~~ [[~~natural killer cells~~]], ~~a type of white blood cell that plays a key role~~ in ~~the body's defense against viruses~~ and ~~cancer~~.		The FCGR2C gene encodes a low-affinity receptor for the Fc region of [[immunoglobulin G]] (IgG). This receptor is expressed on the surface of [[natural killer cells]], [[macrophages]], and other [[leukocytes]]. It is involved in the process of [[antibody-dependent cellular cytotoxicity]] (ADCC), where it helps mediate the destruction of [[target cells]] that are coated with antibodies.

			== Clinical Significance ==
			Variations in the FCGR2C gene have been associated with different [[autoimmune diseases]] and [[inflammatory disorders]]. For example, certain polymorphisms in this gene may influence susceptibility to [[systemic lupus erythematosus]] (SLE) and other [[autoimmune conditions]].

	== ~~Clinical significance~~ ==		== Genetic Variability ==
	~~Mutations in the~~ FCGR2C gene ~~have been associated with susceptibility~~ to [[~~autoimmune diseases]], including [[rheumatoid arthritis~~]] and [[~~systemic lupus erythematosus~~]]~~. In addition, variations in this gene may influence~~ the ~~severity of [[HIV]] infection~~ and ~~the progression~~ to ~~[[AIDS]]~~.		The FCGR2C gene exhibits significant genetic variability, which can affect its expression and function. This variability is due to [[copy number variations]] and [[single nucleotide polymorphisms]] (SNPs) that can alter the receptor's affinity for IgG and its ability to trigger immune responses.

	[[~~File:Fc gamma receptor IIc~~.~~png\|thumb\|right\|Structure~~ of ~~the~~ FCGR2C ~~protein.~~]]		== Research and Implications ==
			Research into the FCGR2C gene and its variants is ongoing, with studies focusing on its role in [[immune regulation]] and its potential as a target for therapeutic interventions in [[autoimmune diseases]]. Understanding the genetic and functional diversity of FCGR2C may lead to improved diagnostic and treatment strategies for conditions involving [[immune dysregulation]].

	== See ~~also~~ ==		== See Also ==
	* [[Fc ~~gamma~~ receptor]]		* [[Fc receptor]]
	* [[Immunoglobulin ~~G]]~~		* [[Immunoglobulin]]
	* [[Phagocytosis]]
	* [[Cytokines]]
	* [[Natural killer cell]]
	* [[Autoimmune disease]]		* [[Autoimmune disease]]
	* [[Rheumatoid arthritis]]
	* [[Systemic lupus erythematosus]]
	* [[HIV]]
	* [[AIDS]]

	== References ==		== References ==
	<references />		<references />

	~~[[Category:Proteins]]~~		== External Links ==
	[~~[Category~~:~~Immunology]~~]		* [NCBI Gene: FCGR2C](https://www.ncbi.nlm.nih.gov/gene/9103)
	~~[[Category~~:~~Genes]]~~		* [UniProt: Q9Y6R4](https://www.uniprot.org/uniprot/Q9Y6R4)
	[~~[Category~~:~~Medical genetics]~~]
	~~[[Category~~:~~Autoimmune diseases]]~~
	~~[[Category:HIV~~/~~AIDS]]~~

	{{~~medicine~~-stub}}		{{Receptor-stub}}
			{{Immune system}}
			[[Category:Genes on human chromosome 1]]
			[[Category:Immune system]]
			[[Category:Receptors]]

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'''FCGR2C''' or '''Fc gamma receptor IIc''' is a protein that in humans is encoded by the FCGR2C gene. It is a member of the [[Fc gamma receptor]] family, which are cell surface receptors found on certain cells in the immune system. These receptors play a key role in the immune response, including the process of [[phagocytosis]] and the release of [[cytokines]].

== Structure ==
The FCGR2C protein is a low affinity receptor for the Fc region of [[immunoglobulin G]] (IgG). It is structurally similar to other Fc gamma receptors, consisting of two extracellular [[immunoglobulin domain|Ig-like domains]], a transmembrane domain, and a cytoplasmic tail. The extracellular domains are responsible for binding to IgG, while the cytoplasmic tail is involved in signal transduction.

== Function ==
FCGR2C is involved in a variety of immune responses. It can mediate phagocytosis, the process by which cells engulf and destroy foreign particles or pathogens. It can also trigger the release of cytokines, which are signaling molecules that regulate immune responses. In addition, FCGR2C can activate [[natural killer cells]], a type of white blood cell that plays a key role in the body's defense against viruses and cancer.

== Clinical significance ==
Mutations in the FCGR2C gene have been associated with susceptibility to [[autoimmune diseases]], including [[rheumatoid arthritis]] and [[systemic lupus erythematosus]]. In addition, variations in this gene may influence the severity of [[HIV]] infection and the progression to [[AIDS]].

[[File:Fc gamma receptor IIc.png|thumb|right|Structure of the FCGR2C protein.]]

== See also ==
* [[Fc gamma receptor]]
* [[Immunoglobulin G]]
* [[Phagocytosis]]
* [[Cytokines]]
* [[Natural killer cell]]
* [[Autoimmune disease]]
* [[Rheumatoid arthritis]]
* [[Systemic lupus erythematosus]]
* [[HIV]]
* [[AIDS]]

== References ==
<references />

[[Category:Proteins]]
[[Category:Immunology]]
[[Category:Genes]]
[[Category:Medical genetics]]
[[Category:Autoimmune diseases]]
[[Category:HIV/AIDS]]

{{medicine-stub}}

FCGR2C - Revision history

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