https://wikimd.org/index.php?action=history&feed=atom&title=Extracellular_signal-regulated_kinases Extracellular signal-regulated kinases - Revision history 2026-04-29T18:14:13Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Extracellular_signal-regulated_kinases&diff=6505634&oldid=prev Prab: CSV import 2025-03-17T11:35:11Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:35, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l29">Line 29:</td> <td colspan="2" class="diff-lineno">Line 29:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Protein-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Protein-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Extracellular_signal-regulated_kinases&diff=6233177&oldid=prev Prab: CSV import 2025-02-10T17:06:34Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:06, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l28">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Protein-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Protein-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Extracellular_signal-regulated_kinases&diff=5898129&oldid=prev Prab: CSV import 2024-06-12T19:34:09Z <p>CSV import</p> <p><b>New page</b></p><div>{{Short description|Protein family involved in cellular signal transduction}}<br /> <br /> &#039;&#039;&#039;Extracellular signal-regulated kinases&#039;&#039;&#039; (&#039;&#039;&#039;ERKs&#039;&#039;&#039;) are a group of protein-serine/threonine kinases that are activated by a variety of extracellular signals. They are part of the [[mitogen-activated protein kinase]] (MAPK) pathway, which plays a crucial role in the regulation of various cellular processes, including [[cell proliferation]], [[differentiation]], and [[survival]].<br /> <br /> ==Structure and Function==<br /> ERKs are typically activated through a phosphorylation cascade initiated by the binding of growth factors, hormones, or other signaling molecules to cell surface receptors. This activation leads to the phosphorylation of ERKs by upstream kinases, such as [[MAP kinase kinase]] (MEK). Once activated, ERKs translocate to the [[cell nucleus]], where they phosphorylate various nuclear targets, including transcription factors, thereby influencing gene expression.<br /> <br /> ==Types of ERKs==<br /> The ERK family consists of several isoforms, with ERK1 and ERK2 being the most studied. These isoforms share significant sequence homology and are often referred to collectively as ERK1/2. Other members of the ERK family include ERK3, ERK4, ERK5, and ERK7, each with distinct regulatory mechanisms and functions.<br /> <br /> ==Role in Disease==<br /> Dysregulation of ERK signaling has been implicated in various diseases, particularly [[cancer]]. Overactivation of ERK pathways can lead to uncontrolled cell growth and proliferation, contributing to tumorigenesis. Inhibitors targeting components of the ERK pathway are being developed as potential therapeutic agents for cancer treatment.<br /> <br /> ==Research and Clinical Implications==<br /> Research on ERKs continues to uncover their roles in different cellular contexts and their potential as targets for therapeutic intervention. Understanding the precise mechanisms of ERK activation and function is crucial for developing effective treatments for diseases associated with ERK dysregulation.<br /> <br /> ==Related Pages==<br /> * [[Mitogen-activated protein kinase]]<br /> * [[Cell signaling]]<br /> * [[Protein kinase]]<br /> * [[Transcription factor]]<br /> * [[Cell proliferation]]<br /> * [[Cancer]]<br /> <br /> [[Category:Signal transduction]]<br /> [[Category:Protein kinases]]<br /> [[Category:Cell biology]]<br /> <br /> {{Protein-stub}}</div> Prab