Prab: CSV import

2025-02-20T01:03:32Z

CSV import

← Older revision		Revision as of 01:03, 20 February 2025
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	[[Category:Transgender and medicine]]		[[Category:Transgender and medicine]]
	{{Medicine-stub}}		{{Medicine-stub}}
			== Estradiol valerate ==
			<gallery>
			File:Estradiol valerate.svg\|Estradiol valerate
			File:Estradiol valerate molecule ball.png\|Estradiol valerate
			File:Progynova (estradiol valerate) tablets in the Chinese mainland.jpg\|Estradiol valerate
			File:Estradiol.svg\|Estradiol
			File:Estradiol levels with oral micronized estradiol and oral estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Estradiol levels after a single dose and with continuous administration of oral estradiol or oral estradiol valerate in women.png\|Estradiol valerate
			File:Hormone levels with oral estradiol valerate tablets (Progynova) taken sublingually in premenopausal women.png\|Estradiol valerate
			File:Estrogen levels after a single intramuscular injection of 10 mg estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Hormone levels after a single intramuscular injection of 5 mg estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Hormone levels in men with a single intramuscular injection of 5 mg estradiol valerate and 50 mg norethisterone enanthate in oil.png\|Estradiol valerate
			File:Estradiol levels after a single 5 mg intramuscular injection of estradiol esters.png\|Estradiol valerate
			File:Estradiol levels after a single intramuscular injection of 10 mg estradiol valerate and 100 mg estradiol undecylate.png\|Estradiol valerate
			</gallery>

Prab: CSV import

2024-03-22T07:42:19Z

CSV import

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'''Estradiol valerate''' is a synthetic [[estrogen]] [[ester]] specifically, the 17β-valerate ester of [[estradiol]], a naturally occurring [[hormone]] that plays a critical role in the regulation of many aspects of the female reproductive system. Estradiol valerate is used in [[hormone therapy]] for menopausal symptoms, as part of feminizing hormone therapy for transgender women, and in hormonal birth control.

==Medical Uses==
Estradiol valerate is utilized in various therapeutic contexts. In [[menopause]] management, it helps alleviate symptoms such as hot flashes, vaginal dryness, and osteoporosis. For transgender women, it is a component of feminizing hormone therapy, promoting the development of female secondary sexual characteristics. Additionally, it is used in some hormonal contraceptives, combined with a [[progestogen]].

==Pharmacology==
===Mechanism of Action===
Estradiol valerate functions by being converted into [[estradiol]] in the body. Estradiol then binds to and activates estrogen receptors throughout the body, mimicking the effects of naturally produced estrogen. This activation influences gene expression and results in the physiological effects associated with estrogen.

===Pharmacokinetics===
After administration, estradiol valerate is rapidly absorbed and converted into estradiol. Its pharmacokinetics are influenced by the route of administration, with oral, injectable, and transdermal forms available. The esterification of estradiol to form estradiol valerate improves the pharmacokinetic profile of estradiol, allowing for more stable blood levels over time.

==Adverse Effects==
The use of estradiol valerate can lead to several adverse effects, including an increased risk of thromboembolic events, such as deep vein thrombosis and pulmonary embolism, especially in smokers and older individuals. Other potential side effects include breast tenderness, nausea, headache, and mood changes. Long-term use has been associated with an increased risk of breast cancer and gallbladder disease.

==Contraindications==
Estradiol valerate is contraindicated in individuals with a history of estrogen-sensitive cancers, uncontrolled hypertension, liver disease, and those who are pregnant or breastfeeding. Caution is advised in patients with a history of thromboembolic disorders.

==Interactions==
Estradiol valerate can interact with various medications, including some anticonvulsants, antifungal agents, and herbal supplements such as St. John's Wort, which may reduce its effectiveness. It is important to consult a healthcare provider about all medications and supplements being taken.

==Dosage and Administration==
The dosage of estradiol valerate varies depending on the indication, route of administration, and individual patient factors. It is crucial to follow a healthcare provider's instructions closely and not to adjust the dose without consultation.

==Society and Culture==
Estradiol valerate plays a significant role in the treatment of menopausal symptoms and in gender-affirming therapy. Its availability and use have evolved over time, reflecting changes in medical practice and societal attitudes towards hormone therapy.

[[Category:Estrogens]]
[[Category:Hormonal therapy]]
[[Category:Transgender and medicine]]
{{Medicine-stub}}

← Older revision		Revision as of 01:03, 20 February 2025
Line 30:		Line 30:
	[[Category:Transgender and medicine]]		[[Category:Transgender and medicine]]
	{{Medicine-stub}}		{{Medicine-stub}}
			== Estradiol valerate ==
			<gallery>
			File:Estradiol valerate.svg\|Estradiol valerate
			File:Estradiol valerate molecule ball.png\|Estradiol valerate
			File:Progynova (estradiol valerate) tablets in the Chinese mainland.jpg\|Estradiol valerate
			File:Estradiol.svg\|Estradiol
			File:Estradiol levels with oral micronized estradiol and oral estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Estradiol levels after a single dose and with continuous administration of oral estradiol or oral estradiol valerate in women.png\|Estradiol valerate
			File:Hormone levels with oral estradiol valerate tablets (Progynova) taken sublingually in premenopausal women.png\|Estradiol valerate
			File:Estrogen levels after a single intramuscular injection of 10 mg estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Hormone levels after a single intramuscular injection of 5 mg estradiol valerate in postmenopausal women.png\|Estradiol valerate
			File:Hormone levels in men with a single intramuscular injection of 5 mg estradiol valerate and 50 mg norethisterone enanthate in oil.png\|Estradiol valerate
			File:Estradiol levels after a single 5 mg intramuscular injection of estradiol esters.png\|Estradiol valerate
			File:Estradiol levels after a single intramuscular injection of 10 mg estradiol valerate and 100 mg estradiol undecylate.png\|Estradiol valerate
			</gallery>

Estradiol valerate - Revision history

Prab: CSV import

Prab: CSV import