Erythema multiforme major - Revision history

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			{{SI}}
			{{Infobox medical condition
			\| name = Erythema multiforme major
			\| image = [[File:Confluent_epidermal_necrosis_-_very_high_mag.jpg\|left\|thumb\|Confluent epidermal necrosis]]
			\| caption = Histopathological image showing confluent epidermal necrosis
			\| field = [[Dermatology]]
			\| synonyms =
			\| symptoms = [[Target lesions]], [[mucosal involvement]], [[fever]], [[malaise]]
			\| complications = [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]]
			\| onset = Sudden
			\| duration = 2–4 weeks
			\| causes = [[Infections]], [[medications]]
			\| risks = [[Herpes simplex virus]], [[Mycoplasma pneumoniae]], certain [[antibiotics]], [[anticonvulsants]]
			\| diagnosis = [[Clinical diagnosis]], [[skin biopsy]]
			\| differential = [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]], [[urticaria]], [[pemphigus]]
			\| prevention = Avoidance of known triggers
			\| treatment = [[Corticosteroids]], [[antihistamines]], [[analgesics]], [[antiviral medications]]
			\| prognosis = Generally good, but depends on severity and complications
			\| frequency = Rare
			}}
	'''Erythema multiforme major''' is a form of [[skin disease]] that is characterized by the sudden onset of red, target-like spots or patches on the skin. It is a severe and potentially life-threatening condition that requires immediate medical attention.		'''Erythema multiforme major''' is a form of [[skin disease]] that is characterized by the sudden onset of red, target-like spots or patches on the skin. It is a severe and potentially life-threatening condition that requires immediate medical attention.

	== Causes ==		== Causes ==

	The exact cause of erythema multiforme major is unknown, but it is often associated with infections, particularly [[herpes simplex virus]] and [[Mycoplasma pneumoniae]]. It can also be triggered by certain medications, including [[sulfa drugs]], [[penicillins]], [[barbiturates]], and [[phenytoin]].		The exact cause of erythema multiforme major is unknown, but it is often associated with infections, particularly [[herpes simplex virus]] and [[Mycoplasma pneumoniae]]. It can also be triggered by certain medications, including [[sulfa drugs]], [[penicillins]], [[barbiturates]], and [[phenytoin]].

	== Symptoms ==		== Symptoms ==

	The primary symptom of erythema multiforme major is the sudden onset of red, target-like spots or patches on the skin. These spots often start on the extremities and spread towards the center of the body. Other symptoms may include fever, general ill feeling, itching of the skin, joint aches, and abnormal [[leukocyte]] count.		The primary symptom of erythema multiforme major is the sudden onset of red, target-like spots or patches on the skin. These spots often start on the extremities and spread towards the center of the body. Other symptoms may include fever, general ill feeling, itching of the skin, joint aches, and abnormal [[leukocyte]] count.

	== Diagnosis ==		== Diagnosis ==

	Diagnosis of erythema multiforme major is typically based on the characteristic appearance of the skin lesions. Additional tests may be performed to rule out other conditions and to identify any underlying causes. These tests may include a [[skin biopsy]], blood tests, and tests for specific infections.		Diagnosis of erythema multiforme major is typically based on the characteristic appearance of the skin lesions. Additional tests may be performed to rule out other conditions and to identify any underlying causes. These tests may include a [[skin biopsy]], blood tests, and tests for specific infections.

	== Treatment ==		== Treatment ==

	Treatment for erythema multiforme major is primarily supportive and aimed at relieving symptoms. This may include the use of [[corticosteroids]] to reduce inflammation, [[antihistamines]] to relieve itching, and pain medications to manage discomfort. If an underlying infection is identified, appropriate [[antibiotics]] or antiviral medications may be prescribed.		Treatment for erythema multiforme major is primarily supportive and aimed at relieving symptoms. This may include the use of [[corticosteroids]] to reduce inflammation, [[antihistamines]] to relieve itching, and pain medications to manage discomfort. If an underlying infection is identified, appropriate [[antibiotics]] or antiviral medications may be prescribed.

	== Prognosis ==		== Prognosis ==

	The prognosis for erythema multiforme major varies depending on the severity of the condition and the individual's overall health. With appropriate treatment, most people recover within 2 to 6 weeks. However, the condition can recur, particularly in individuals with herpes simplex virus.		The prognosis for erythema multiforme major varies depending on the severity of the condition and the individual's overall health. With appropriate treatment, most people recover within 2 to 6 weeks. However, the condition can recur, particularly in individuals with herpes simplex virus.

	== See also ==		== See also ==

	* [[Erythema multiforme minor]]		* [[Erythema multiforme minor]]
	* [[Stevens-Johnson syndrome]]		* [[Stevens-Johnson syndrome]]
	* [[Toxic epidermal necrolysis]]		* [[Toxic epidermal necrolysis]]

	[[Category:Skin diseases]]		[[Category:Skin diseases]]
	[[Category:Medical conditions]]		[[Category:Medical conditions]]
	[[Category:Dermatology]]		[[Category:Dermatology]]

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	~~<gallery>~~
	~~File:Confluent epidermal necrosis - very high mag.jpg\|Erythema multiforme major~~
	~~</gallery>~~

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'''Erythema multiforme major''' is a form of [[skin disease]] that is characterized by the sudden onset of red, target-like spots or patches on the skin. It is a severe and potentially life-threatening condition that requires immediate medical attention.

== Causes ==

The exact cause of erythema multiforme major is unknown, but it is often associated with infections, particularly [[herpes simplex virus]] and [[Mycoplasma pneumoniae]]. It can also be triggered by certain medications, including [[sulfa drugs]], [[penicillins]], [[barbiturates]], and [[phenytoin]].

== Symptoms ==

The primary symptom of erythema multiforme major is the sudden onset of red, target-like spots or patches on the skin. These spots often start on the extremities and spread towards the center of the body. Other symptoms may include fever, general ill feeling, itching of the skin, joint aches, and abnormal [[leukocyte]] count.

== Diagnosis ==

Diagnosis of erythema multiforme major is typically based on the characteristic appearance of the skin lesions. Additional tests may be performed to rule out other conditions and to identify any underlying causes. These tests may include a [[skin biopsy]], blood tests, and tests for specific infections.

== Treatment ==

Treatment for erythema multiforme major is primarily supportive and aimed at relieving symptoms. This may include the use of [[corticosteroids]] to reduce inflammation, [[antihistamines]] to relieve itching, and pain medications to manage discomfort. If an underlying infection is identified, appropriate [[antibiotics]] or antiviral medications may be prescribed.

== Prognosis ==

The prognosis for erythema multiforme major varies depending on the severity of the condition and the individual's overall health. With appropriate treatment, most people recover within 2 to 6 weeks. However, the condition can recur, particularly in individuals with herpes simplex virus.

== See also ==

* [[Erythema multiforme minor]]
* [[Stevens-Johnson syndrome]]
* [[Toxic epidermal necrolysis]]

[[Category:Skin diseases]]
[[Category:Medical conditions]]
[[Category:Dermatology]]

{{stub}}