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	[[Category:Alzheimer's disease]]		[[Category:Alzheimer's disease]]
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			==Entorhinal_cortex==
			<gallery>
			File:Gray-Brodman-Entorhinal_Cortex_EC_.png\|Brodmann area of the entorhinal cortex
			File:Medial_surface_of_cerebral_cortex_-_entorhinal_cortex.png\|Medial surface of cerebral cortex highlighting the entorhinal cortex
			File:Apoe-cortical-thickness-entorhinal.jpg\|Cortical thickness in the entorhinal region
			File:Entorhinal_-_DK_ATLAS.png\|Entorhinal cortex as shown in the DK Atlas
			</gallery>

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'''Entorhinal Cortex'''

The '''[[Entorhinal Cortex]]''' is an area of the [[brain]] located in the [[medial temporal lobe]] and functions as a hub in a widespread network for memory and navigation. The entorhinal cortex is noted for its distinctive role in [[memory]] and [[navigation]].

== Anatomy ==

The entorhinal cortex is located in the [[temporal lobe]] and is often divided into two areas based on the type of [[neurons]] that are present. The medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC) have different functions because they connect to different areas of the brain.

== Function ==

The entorhinal cortex plays a crucial role in [[memory formation]] and [[spatial navigation]]. It is one of the first regions to be affected by [[neurodegenerative]] diseases such as [[Alzheimer's disease]].

=== Memory ===

The entorhinal cortex is a significant gateway for information going into and out of the [[hippocampus]], a region of the brain crucial for [[memory consolidation]]. The entorhinal cortex-hippocampus system plays a substantial role in [[declarative memory]] (memories which can be consciously recalled).

=== Navigation ===

The entorhinal cortex is also essential for spatial navigation. The medial entorhinal cortex is especially important in this regard, as it contains "grid cells." These [[grid cells]] are neurons that have a specific pattern of activity when an animal is navigating through space.

== Clinical significance ==

The entorhinal cortex is one of the first areas to be affected in [[Alzheimer's disease]], which leads to the memory loss and disorientation associated with the disease.

== See also ==

* [[Grid cell]]
* [[Memory]]
* [[Alzheimer's disease]]
* [[Hippocampus]]
* [[Temporal lobe]]

== References ==

{{reflist}}

[[Category:Neuroanatomy]]
[[Category:Memory]]
[[Category:Alzheimer's disease]]
{{Neuroscience-stub}}

Entorhinal cortex - Revision history

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