https://wikimd.com/index.php?action=history&feed=atom&title=Entinostat 2026-04-24T15:15:41Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Entinostat&diff=5368757&oldid=prev 2024-03-06T04:24:07Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Entinostat.png|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;Entinostat&#039;&#039;&#039;<br /> <br /> Entinostat, also known by its trade name [[SNDX-275]], is a [[histone deacetylase inhibitor]] (HDAC inhibitor) that is used in [[cancer]] treatment. It is a synthetic benzamide derivative that has been shown to have antineoplastic activity.<br /> <br /> ==Mechanism of Action==<br /> <br /> Entinostat inhibits the activity of [[histone deacetylase]], an enzyme that is involved in the regulation of [[gene expression]]. By inhibiting this enzyme, entinostat can alter the expression of genes that are involved in cell growth and differentiation, leading to the death of cancer cells.<br /> <br /> ==Clinical Use==<br /> <br /> Entinostat is used in the treatment of various types of cancer, including [[breast cancer]], [[lung cancer]], and [[leukemia]]. It is often used in combination with other [[chemotherapy]] drugs to enhance their effectiveness.<br /> <br /> ==Side Effects==<br /> <br /> Common side effects of entinostat include [[fatigue]], [[nausea]], and [[vomiting]]. More serious side effects can include [[anemia]], [[neutropenia]], and [[thrombocytopenia]].<br /> <br /> ==Research==<br /> <br /> Research is ongoing to determine the full range of cancers that can be treated with entinostat, as well as to better understand its mechanism of action. Clinical trials are also being conducted to evaluate the safety and effectiveness of entinostat in combination with other drugs.<br /> <br /> ==See Also==<br /> <br /> * [[Histone deacetylase inhibitor]]<br /> * [[Cancer treatment]]<br /> * [[Chemotherapy]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Cancer treatment]]<br /> [[Category:Histone deacetylase inhibitors]]<br /> <br /> {{pharmacology-stub}}<br /> {{cancer-stub}}</div>

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