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2025-02-16T06:03:47Z

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← Older revision		Revision as of 06:03, 16 February 2025
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	~~'''~~Enterohepatic circulation''' refers to the circulation of biliary acids, bilirubin, drugs, or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.		{{DISPLAYTITLE:Enterohepatic Circulation}}

	== ~~Overview~~ ==		== Enterohepatic Circulation ==
			[[File:Enterohepatic.svg\|thumb\|right\|Diagram of the enterohepatic circulation]]
			The '''enterohepatic circulation''' refers to the circulation of bile acids, bilirubin, drugs, and other substances from the [[liver]] to the [[bile]], followed by entry into the [[small intestine]], absorption by the enterocytes, and transport back to the liver. This process is crucial for the digestion and absorption of [[lipids]] and fat-soluble vitamins, as well as the detoxification and excretion of various substances.

	The [[liver]] plays a crucial role in the enterohepatic circulation. It produces [[bile]], a fluid containing water, bile acids, and several waste products. Bile is stored in the [[gallbladder]] and released into the [[small intestine]] during digestion.		== Components of Enterohepatic Circulation ==

	In the ~~small intestine,~~ bile ~~acids aid~~ in the ~~digestion~~ and absorption of dietary fats. After ~~completing their role~~, ~~they~~ are reabsorbed ~~into~~ the ~~bloodstream~~ and returned to the liver~~, where they are reused. This process is known as~~ the ~~enterohepatic circulation~~.		=== Bile Acids ===
			Bile acids are synthesized in the liver from [[cholesterol]] and are secreted into the bile. They play a key role in the emulsification and absorption of dietary fats in the small intestine. After aiding in digestion, bile acids are reabsorbed in the ileum and returned to the liver via the [[portal vein]].

	== ~~Function~~ ==		=== Bilirubin ===
			[[Bilirubin]] is a byproduct of the breakdown of [[hemoglobin]] from red blood cells. It is conjugated in the liver and excreted into the bile. In the intestine, bilirubin is converted into urobilinogen, some of which is reabsorbed and returned to the liver, while the rest is excreted in the feces.

	~~The primary function of the~~ enterohepatic circulation ~~is to conserve bile acids, which are synthesized from cholesterol~~ in the liver, ~~secreted~~ into the bile, and ~~passed into~~ the ~~small~~ intestine.		=== Drugs and Toxins ===
			Many drugs and toxins undergo enterohepatic circulation. After being metabolized in the liver, they are excreted into the bile and can be reabsorbed in the intestine, prolonging their presence in the body.

	In the ~~intestine,~~ bile acids ~~emulsify dietary fats~~ and ~~facilitate their absorption~~. ~~Approximately 95%~~ of ~~the~~ bile acids ~~are reabsorbed~~ in the ~~terminal ileum~~ and ~~transported back to~~ the ~~liver via the portal vein~~.		== Physiological Importance ==
			The enterohepatic circulation is essential for maintaining the body's [[homeostasis]] of bile acids and cholesterol. It allows for the efficient recycling of bile acids, reducing the need for de novo synthesis. This circulation also plays a role in the regulation of [[lipid metabolism]] and the detoxification of harmful substances.

	== Clinical ~~significance~~ ==		== Clinical Significance ==
			Disruptions in enterohepatic circulation can lead to various medical conditions. For example, impaired reabsorption of bile acids can result in [[bile acid malabsorption]], leading to diarrhea and malabsorption of fats. Additionally, certain liver diseases can affect the enterohepatic circulation, impacting the body's ability to process and excrete bilirubin and other substances.

	Disruption of the enterohepatic circulation can lead to several health problems. For instance, if bile acids are not properly reabsorbed, they can cause [[diarrhea]] or [[malabsorption]] of dietary fats and fat-soluble vitamins.		== Related Pages ==

	Certain drugs can also affect the enterohepatic circulation. For example, [[cholestyramine]], a bile acid sequestrant, binds to bile acids in the intestine and prevents their reabsorption. This drug is used to lower cholesterol levels in the body.

	== ~~See also~~ ==

	* [[Bile acid]]
	* [[Liver]]		* [[Liver]]
			* [[Bile]]
	* [[Small intestine]]		* [[Small intestine]]
	* [[~~Gallbladder~~]]		* [[Portal vein]]
	* [[~~Cholestyramine~~]]		* [[Cholesterol]]
			* [[Bilirubin]]

	~~[[Category:Digestive system]]~~
	[[Category:Hepatology]]		[[Category:Hepatology]]
	[[Category:~~Pharmacokinetics~~]]		[[Category:Gastroenterology]]

	~~{{stub}}~~

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2024-02-22T21:07:28Z

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'''Enterohepatic circulation''' refers to the circulation of biliary acids, bilirubin, drugs, or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.

== Overview ==

The [[liver]] plays a crucial role in the enterohepatic circulation. It produces [[bile]], a fluid containing water, bile acids, and several waste products. Bile is stored in the [[gallbladder]] and released into the [[small intestine]] during digestion.

In the small intestine, bile acids aid in the digestion and absorption of dietary fats. After completing their role, they are reabsorbed into the bloodstream and returned to the liver, where they are reused. This process is known as the enterohepatic circulation.

== Function ==

The primary function of the enterohepatic circulation is to conserve bile acids, which are synthesized from cholesterol in the liver, secreted into the bile, and passed into the small intestine.

In the intestine, bile acids emulsify dietary fats and facilitate their absorption. Approximately 95% of the bile acids are reabsorbed in the terminal ileum and transported back to the liver via the portal vein.

== Clinical significance ==

Disruption of the enterohepatic circulation can lead to several health problems. For instance, if bile acids are not properly reabsorbed, they can cause [[diarrhea]] or [[malabsorption]] of dietary fats and fat-soluble vitamins.

Certain drugs can also affect the enterohepatic circulation. For example, [[cholestyramine]], a bile acid sequestrant, binds to bile acids in the intestine and prevents their reabsorption. This drug is used to lower cholesterol levels in the body.

== See also ==

* [[Bile acid]]
* [[Liver]]
* [[Small intestine]]
* [[Gallbladder]]
* [[Cholestyramine]]

[[Category:Digestive system]]
[[Category:Hepatology]]
[[Category:Pharmacokinetics]]

{{stub}}

Enterohepatic circulation - Revision history

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