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Endothelin receptor - Revision history
2026-04-27T06:16:41Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=Endothelin_receptor&diff=6528193&oldid=prev
Prab at 17:23, 18 March 2025
2025-03-18T17:23:57Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:23, 18 March 2025</td>
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Prab: CSV import
2025-03-17T10:53:32Z
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Prab: CSV import
2025-02-10T16:32:58Z
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Prab: CSV import
2024-02-28T22:15:58Z
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<p><b>New page</b></p><div>'''Endothelin receptor''' is a type of [[G protein-coupled receptor]] that is activated by the [[protein]] [[endothelin]]. There are two types of endothelin receptors: ET<sub>A</sub> and ET<sub>B</sub>. These receptors play a crucial role in [[vasoconstriction]], [[cell proliferation]], and [[neurotransmission]].<br />
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== Structure ==<br />
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Endothelin receptors are integral membrane proteins that contain seven transmembrane domains, which is a common characteristic of G protein-coupled receptors. The ET<sub>A</sub> and ET<sub>B</sub> receptors share a 63% amino acid sequence identity.<br />
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== Function ==<br />
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Endothelin receptors are found in various tissues, including the [[vascular smooth muscle]], [[heart]], [[lung]], and [[kidney]]. They are involved in a variety of physiological processes.<br />
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=== ET<sub>A</sub> Receptor ===<br />
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The ET<sub>A</sub> receptor primarily mediates vasoconstriction and cell proliferation. It is predominantly found in vascular smooth muscle cells. Activation of the ET<sub>A</sub> receptor by endothelin leads to [[vasoconstriction]] and [[cell proliferation]].<br />
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=== ET<sub>B</sub> Receptor ===<br />
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The ET<sub>B</sub> receptor has a dual role. It is located in the endothelial cells where it mediates [[vasodilation]] by releasing [[nitric oxide]] and [[prostacyclin]]. It is also found in smooth muscle cells where it mediates vasoconstriction.<br />
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== Clinical significance ==<br />
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Endothelin receptors have been implicated in a variety of diseases, including [[pulmonary arterial hypertension]], [[heart failure]], and [[cancer]]. Antagonists of the endothelin receptor, such as [[bosentan]], [[ambrisentan]], and [[macitentan]], are used clinically to treat pulmonary arterial hypertension.<br />
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== See also ==<br />
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* [[Endothelin]]<br />
* [[G protein-coupled receptor]]<br />
* [[Vasoconstriction]]<br />
* [[Cell proliferation]]<br />
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[[Category:G protein-coupled receptors]]<br />
[[Category:Signal transduction]]<br />
[[Category:Human proteins]]<br />
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{{GPCR-stub}}<br />
{{Medicine-stub}}</div>
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