https://wikimd.org/index.php?action=history&feed=atom&title=EndostatinEndostatin - Revision history2026-04-26T05:43:31ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Endostatin&diff=5803031&oldid=prevPrab: CSV import2024-05-19T22:02:12Z<p>CSV import</p>
<p><b>New page</b></p><div>[[image:endostatin.jpeg|thumb|left]] '''Endostatin''' is a naturally occurring [[protein]] that inhibits [[angiogenesis]], the process through which new [[blood vessels]] form from pre-existing vessels. It is a fragment of [[collagen XVIII]], a type of [[collagen]] found in the [[extracellular matrix]] of various tissues. Endostatin has been studied for its potential use in [[cancer]] treatment due to its ability to suppress the growth of [[tumors]] by cutting off their blood supply.<br />
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== Discovery and Structure ==<br />
Endostatin was first discovered in 1997 by Dr. [[Judah Folkman]] and his team at [[Children's Hospital Boston]]. It is a 20 kDa protein that is derived from the C-terminal fragment of collagen XVIII. The structure of endostatin includes a compact, globular domain that is stabilized by [[disulfide bonds]].<br />
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== Mechanism of Action ==<br />
Endostatin exerts its anti-angiogenic effects by binding to various receptors on the surface of [[endothelial cells]], which are the cells that line the interior surface of blood vessels. This binding inhibits the proliferation, migration, and tube formation of endothelial cells, thereby preventing the formation of new blood vessels. Endostatin also interferes with the signaling pathways of [[vascular endothelial growth factor]] (VEGF) and [[fibroblast growth factor]] (FGF), both of which are critical for angiogenesis.<br />
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== Clinical Applications ==<br />
Endostatin has been investigated in several [[clinical trials]] for its potential use in treating various types of cancer, including [[lung cancer]], [[breast cancer]], and [[prostate cancer]]. Although initial results were promising, subsequent studies have shown mixed outcomes regarding its efficacy. Researchers continue to explore the optimal dosing, delivery methods, and combination therapies to enhance the therapeutic potential of endostatin.<br />
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== Research and Development ==<br />
Ongoing research is focused on understanding the detailed mechanisms of endostatin's action, improving its stability and bioavailability, and developing novel delivery systems such as [[nanoparticles]] and [[gene therapy]] approaches. Additionally, studies are being conducted to identify biomarkers that can predict patient response to endostatin treatment.<br />
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== See Also ==<br />
* [[Angiogenesis]]<br />
* [[Collagen]]<br />
* [[Cancer treatment]]<br />
* [[Judah Folkman]]<br />
* [[Vascular endothelial growth factor]]<br />
* [[Fibroblast growth factor]]<br />
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== References ==<br />
{{Reflist}}<br />
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== External Links ==<br />
{{Commons category|Endostatin}}<br />
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[[Category:Proteins]]<br />
[[Category:Angiogenesis inhibitors]]<br />
[[Category:Cancer treatments]]<br />
[[Category:Biotechnology]]<br />
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